1,2,3,6-TETRAHYDROPYRIDINE Chemical Properties

Melting point:

−48 °C(lit.)

Boiling point:

108 °C(lit.)

Density 

0.911 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.48(lit.)

Flash point:

61 °F

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Powder

pka

10.22±0.10(Predicted)

color 

White to pale yellow-cream

Stability:

Light Sensitive

CAS DataBase Reference

694-05-3(CAS DataBase Reference)

EPA Substance Registry System

Pyridine, 1,2,3,6-tetrahydro- (694-05-3)

Safety Information

Hazard Codes 

F,Xi

Risk Statements 

11-36/37/38

Safety Statements 

16-26-36/37/39

RIDADR 

UN 2410 3/PG 2

WGK Germany 

3

Hazard Note 

Irritant/Highly Flammable

HazardClass 

3.1

PackingGroup 

II

HS Code 

29333999

MSDS

• Language:English Provider:SigmaAldrich

1,2,3,6-TETRAHYDROPYRIDINE Usage And Synthesis

Chemical Properties

Clear colorless to pale yellow liquid

Uses

Organic intermediate.

Uses

Used to form ene-endo-spirocyclic ammonium ylids for [2,3]-sigmatropic rearrangement to pyrroloazepinones and oxazepinones.

Definition

ChEBI: 3-piperideine is a piperideine.

General Description

A colorless liquid. Density 0.913 g / cm3 and insoluble in water. Hence floats on water. Flash point near 110°F. Vapors heavier than air. Used to make other chemicals.

Air & Water Reactions

Flammable. Insoluble in water.

Reactivity Profile

1,2,3,6-TETRAHYDROPYRIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

Fire Hazard

HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

1,2,3,6-TETRAHYDROPYRIDINE(694-05-3)Related Product Information

• 1,2,3,6-Tetrahydro-4-phenyl-pyridine
• 4-(4-CHLOROPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE
• Arecoline hydrobromide
• LYSERGOL
• ARECAIDINE HYDROCHLORIDE
• 1,2,3,6-TETRAHYDROPYRIDINE
• 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
• GUVACINE HYDROCHLORIDE
• 4-(4-FLUOROPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE
• ARECOLINE HYDROCHLORIDE
• 1,3-DIHYDRO-1-(1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-2H-BENZIMIDAZOLE-2-ONE
• Pyrido[4,3-d]pyrimidine, 4-chloro-5,6,7,8-tetrahydro-
• 4,5,6,7-Tetrahydro-3-hydroxy-[1,2,3]oxadiazolo[3,4-a]pyridin-8-ium inner salt
• METHYL 4-AMINO-1-BENZYL-1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXYLATE, 99
• 2,4-Dichloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine
• N-BOC-3-HYDROXY-1,2,3,6-TETRAHYDROPYRIDINE
• Benzyl 4-(chlorocarbonyl)tetrahydro-1(2H)-pyridinecarboxylate
• 2-chloro-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine