1,3-Diphenylurea Chemical Properties

Melting point:

239-241 °C(lit.)

Boiling point:

262 °C(lit.)

Density 

1,239 g/cm³

vapor pressure 

0-0Pa at 20-25℃

refractive index 

1.6920 (estimate)

Flash point:

260°C

storage temp. 

Sealed in dry,Room Temperature

solubility 

pyridine: soluble50mg/mL, clear to very slightly hazy, colorless to faintly yellow

form 

Crystalline Powder

pka

14.15±0.70(Predicted)

color 

White

Water Solubility 

150.3mg/L(temperature not stated)

Merck 

14,1785

BRN 

782650

Stability:

Stable. Incompatible with strong oxidizing agents.

InChIKey

GWEHVDNNLFDJLR-UHFFFAOYSA-N

LogP

2.97

CAS DataBase Reference

102-07-8(CAS DataBase Reference)

NIST Chemistry Reference

Urea, N,N'-diphenyl-(102-07-8)

EPA Substance Registry System

Carbanilide (102-07-8)

Safety Information

Safety Statements 

22-24/25

RIDADR 

2811

WGK Germany 

3

RTECS 

FD9800000

TSCA 

Yes

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29242100

Hazardous Substances Data

102-07-8(Hazardous Substances Data)

Toxicity

mouse,LD50,intraperitoneal,200mg/kg (200mg/kg),National Technical Information Service. Vol. AD277-689,

MSDS

• Language:English Provider:N,N'-Diphenylurea
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1,3-Diphenylurea Usage And Synthesis

Chemical Properties

1,3-Diphenylurea is supplied as a solid. A stock solution may be made by dissolving the 1,3-diphenylureain, the solvent of choice, which should be purged with an inert gas. 1,3-Diphenylurea is soluble in organic solvents such as DMSO and dimethyl formamide. The solubility of 1,3-diphenylurea in these solvents is approximately 30 mg/ml.1,3-Diphenylurea is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers1,3-diphenylurea should first be dissolved in DMSO and then diluted with the aqueous buffer of choice.1,3-Diphenylurea has a solubility of approximately 50 ug/ml in a 1:20 solution of DMSO: PBS (pH 7.2) using this method.

Definition

ChEBI: 1,3-diphenylurea is a member of the class of phenylureas that is urea in which one of the hydrogens of each amino group is replaced by a phenyl group. It is present in coconut milk (Cocos nucifera). It has a role as a plant metabolite and a cytokinin.

Production Methods

N,N'-Diphenylurea, carbanilide, can be produced in high yields by heating 2 mol of aniline with 1 mol of urea in glacial acetic acid.

Synthesis Reference(s)

Chemical and Pharmaceutical Bulletin, 29, p. 3075, 1981
Chemistry Letters, 14, p. 603, 1985
Tetrahedron Letters, 15, p. 1191, 1974 DOI: 10.1016/S0040-4039(01)82442-4

General Description

1,3-Diphenylurea is a cytokinin compound present in fruit and vegetables.

Biochem/physiol Actions

1,3-Diphenylurea is metabolized by a moderate halophilic Marinobacter sp. isolated from a contaminated ephemeral desert stream bed in Negev desert.

1,3-Diphenylurea (102-07-8)Related Product Information

• Direct Red 23
• Direct Red 75 tetrasodium salt
• CALCOMINE ORANGE 2RS
• Imidocarb
• Triclocarban
• DIRECT YELLOW 50
• N,N'-BIS(PENTAFLUOROPHENYL)UREA
• N,N'-Diphenylurea
• 1,3-BIS(4-NITROPHENYL)UREA
• TRIMETHYLSILYL-N,N'-DIPHENYLUREA,TRIMETHYLSILYL-N N-DIPHENYLUREA,N-Trimethylsilyl-N,N’-diphenylure
• 1,3-Diethyl-1,3-diphenylurea
• 1,3-di-p-tolylurea
• 1,3-Dimethyl-1,3-diphenylurea
• DIPHENYLUREA CHLORIDE
• Urea
• Phenylurea
• N,N'-BIS(P-CHLOROPHENYL)UREA
• 4-[(ANILINOCARBONYL)AMINO]BENZOIC ACID