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Quinine hydrochloride

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Quinine hydrochloride Basic information

Product Name:
Quinine hydrochloride
Synonyms:
  • QUININE HCL
  • QUININE HYDROCHLORIDE
  • QUININE MONOHYDROCHLORIDE
  • 6’-methoxy-,monohydrochloride,(8.alpha.,9R)-Cinchonan-9-ol
  • 6’-methoxy-,monohydrochloride,(8-alpha,9r)-cinchonan-9-o
  • 6’-methoxy-,monohydrochloride,(8alpha,9theta)-cinchonan-9-o
  • chinimetten
  • quininechloride
CAS:
130-89-2
MF:
C20H25ClN2O2
MW:
360.88
EINECS:
205-001-1
Mol File:
130-89-2.mol
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Quinine hydrochloride Chemical Properties

Melting point:
158-160 C
Density 
1.1206 (rough estimate)
refractive index 
1.5400 (estimate)
FEMA 
2976 | QUININE HYDROCHLORIDE
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
DMSO (Slightly), Ethanol (1g/1ml), glycerol(1g/7ml), chloroform(1g/1ml)
form 
Solid
color 
White
Water Solubility 
549.7mg/L(25 ºC)
EPA Substance Registry System
Cinchonan-9-ol, 6'-methoxy-, hydrochloride (1:1), (8.alpha.,9R)- (130-89-2)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36-24/25
RIDADR 
1544
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
29392000
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Quinine hydrochloride Usage And Synthesis

Chemical Properties

Quinine hydrochloride is a white, silky, glittering needles; odourless, effloresces when exposed to warm air. Soluble in water, very soluble in ethanol, freely soluble in chloroform, insoluble in ether. Its solutions are neutral or alkaline to litmus. It is an alkaloid derived from the bark of the cinchona tree. Quinine Hydrochloride is used as ingredient of beverages and injection medication.

Uses

Quinine Hydrochloride is used as an antimalarial drug, and is the active ingredient in extracts of the cinchona that have been used for that purpose since before 1633. Quinine is also a mild antipyretic and analgesic and has been used in common cold preparations for that purpose. It was used commonly and as a bitter and flavoring agent, and is still useful for the treatment of babesiosis. Quinine is also useful in some muscular disorders, especially nocturnal leg cramps and myotonia congenita, because of its direct effects on muscle membrane and sodium channels. The mechanisms of its antimalarial effects are not well understood.

Definition

Quinine Hydrochloride is the hydrochloride of a natural substance, quinine, obtained from the bark of various species of Cinchona including Cinchona succirubra, Pavon. (red cinchona); Cinchona officinalis, Linn; Cinchona calizaya, Wenddell; Cinchona ledgeriana, Moens. It is a nature-derived bitter flavoring agent for tonic water, among other beverages.

Biological Activity

Quinine hydrochloride is a displays antimalarial and muscle relaxant properties. Stereoisomer of quinidine; closely related to chloroquine.?

Safety Profile

Poison by ingestion, subcutaneous, intravenous, intramuscular, and intraperitoneal routes. Human systemic effects by intravenous route: convulsions or effect on seizure threshold, muscle contraction or spasticity, and nausea or vomiting. Mutation data reported. Used as a local anesthetic. When heated to decomposition it emits very toxic fumes of NO, and HCI. See also QUININE.

Synthesis

Manufacture of quinine by extraction from Cinchona bark and subsequent purification and synthesis to quinine hydrochloride.

Quinine hydrochloride Preparation Products And Raw materials

Raw materials

Quinine hydrochlorideSupplier

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