GAMMA-LINOLENIC ACID METHYL ESTER
GAMMA-LINOLENIC ACID METHYL ESTER Basic information
- Product Name:
- GAMMA-LINOLENIC ACID METHYL ESTER
- Synonyms:
-
- DELTA 6 CIS 9 CIS 12 CIS OCTADECATRIENOIC ACID METHYL ESTER
- FAME 18:3N-6
- GAMMA-LINOLENIC ACID METHYL ESTER
- C18:3 (ALL CIS-6,9,12) METHYL ESTER
- METHYL GAMMA-LINOLENATE
- METHYL GLA
- METHYL-GAMA-LINOLENATE
- METHYL (Z,Z,Z)-6,9,12-OCTADECATRIENOATE
- CAS:
- 16326-32-2
- MF:
- C19H32O2
- MW:
- 292.46
- Mol File:
- 16326-32-2.mol
GAMMA-LINOLENIC ACID METHYL ESTER Chemical Properties
- Boiling point:
- 162 °C0.5 mm Hg(lit.)
- Density
- 0.9019 g/cm3
- refractive index
- n20/D 1.476(lit.)
- Flash point:
- 62 °C
- storage temp.
- -20°C
- solubility
- ≤100mg/ml in DMSO;100mg/ml in dimethyl formamide
- form
- Liquid
- color
- Colorless to light yellow
MSDS
- Language:English Provider:SigmaAldrich
GAMMA-LINOLENIC ACID METHYL ESTER Usage And Synthesis
Description
Polyunsaturated fatty acids (PUFAs) are essential nutrients that show distinct deficiency syndromes when not present in adequate amounts in the diet. γ-
Uses
Methyl γ-linolenate may be used as an analytical standard for the determination of aldehydes such as pentanal and hexanal via peroxidation, further analyzed by gas chromatography technique. It may also be used as an analytical reference standard for the quantification of the analyte in serum lipid extract and Arthrospira (Spirulina) platensis using the gas-chromatography technique.
Definition
ChEBI: Methyl gamma-linolenate is a fatty acid methyl ester obtained from the formal condensation of methanol and gamma-linolenic acid. It has a role as a bacterial metabolite, an apoptosis inducer, an antineoplastic agent and an antibacterial agent. It is functionally related to a gamma-linolenic acid.
Biochem/physiol Actions
Methyl γ-linolenate (C18:6,9,12) differs from methyl α-linolenate (C18:9,12,15) in the positions of the double bonds. Methyl γ-linolenate may be used in nutritional studies regarding weight regain and as a possible tumor suppression agent.
in vitro
γ-linolenic acid methyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of gla-containing diets and dietary supplements. gla was identified as an ω-6 fatty acid which could be elongated to arachidonic acid for endogenous eicosanoid synthesis. gla was found to be a weak leukotriene b4 (ltb4) receptor antagonist, which was able to inhibit [3h]-ltb4 binding to porcine neutrophil membranes with a ki of 1 μm [1].
in vivo
in an in-vivo model of ltb4-induced bronchoconstriction, ricinelaidic acid andγ-linolenic acid methyl ester at a 1 mg/kg i.v. dose could result in 46% and 53% inhibition, respectively, indicating that essential fatty acids are ltb4 receptor antagonists, which may account in part for their reported anti-inflammatory activities [1].
References
[1] yagaloff, k. a.,franco, l.,simko, b., et al. essential fatty acids are antagonists of the leukotriene b4 receptor. prostaglandins, leukotrienes and essential fatty acids 52, 293-297 (1995).
GAMMA-LINOLENIC ACID METHYL ESTER Preparation Products And Raw materials
Preparation Products
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GAMMA-LINOLENIC ACID METHYL ESTER(16326-32-2)Related Product Information
- N-γ-LinolenoylethanolaMine
- Linoleic acid
- Linolenic acid
- gamma-Linolenic acid
- Methyl?Gamma?Linolenate?(6c,?9c,?12c)
- DIHOMO-GAMMA-LINOLENIC ACID METHYL ESTER
- METHYL LINOLENATE
- METHYL LINOLENATE
- DELTA 6 CIS, 9 CIS, 12 CIS MONO(GAMMA) LINOLENIN
- 1,2-OLEIN-3-LINOLENIN
- 1,3-DIGAMMA LINOLENIN
- DELTA 6 CIS, 9 CIS, 12 CIS DIGAMMA LINOLENIN
- GAMMA-LINOLENIC ACID ETHYL ESTER
- TRIGAMMALINOLENIN
- GAMMA-LINOLENIC ACID METHYL ESTER