4-Bromo-3-fluorobenzaldehyde Chemical Properties

Melting point:

55-59 °C

Boiling point:

240.2±25.0 °C(Predicted)

Density 

1.670±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

soluble in Methanol

form 

powder to crystal

color 

White to Light yellow

InChI

InChI=1S/C7H4BrFO/c8-6-2-1-5(4-10)3-7(6)9/h1-4H

InChIKey

SWHUROFMIMHWKS-UHFFFAOYSA-N

SMILES

C(=O)C1=CC=C(Br)C(F)=C1

CAS DataBase Reference

133059-43-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-36-22

Safety Statements 

26-36/37/39

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29130000

4-Bromo-3-fluorobenzaldehyde Usage And Synthesis

Chemical Properties

White powder

Uses

4-Bromo-3-fluorobenzaldehyde is used in preparation of the Deuterated Dihydropyrimidine compound and their application as anti-HBV agent.

Synthesis

General procedure for the synthesis of 3-fluoro-4-bromobenzaldehyde from 4-bromo-3-fluorobenzyl alcohol: Manganese dioxide (18.7 g, 210 mmol) was added to a solution of 4-bromo-3-fluorobenzyl alcohol (4.3 g, 21 mmol) in chloroform (50 mL), and the reaction mixture was stirred at 37 °C overnight. The progress of the reaction was monitored by thin layer chromatography (TLC) until the raw material was completely consumed. Upon completion of the reaction, the mixture was filtered and the filtrate was concentrated under reduced pressure to afford the target product 3-fluoro-4-bromobenzaldehyde (2.3 g, 55% yield).

References

[1] Patent: US2010/216806, 2010, A1. Location in patent: Page/Page column 103
[2] Patent: US6297239, 2001, B1

4-Bromo-3-fluorobenzaldehyde(133059-43-5)Related Product Information

• 4-Fluorobenzaldehyde
• 4-Fluorobenzonitrile
• 4-Bromofluorobenzene
• 4-Bromo-3-fluorobenzoic acid
• 1,3-Difluorobenzene
• Transfluthrin
• 4-Bromobenzaldehyde
• Florfenicol
• 3-Fluorobenzaldehyde
• 4-BROMO-3-FLUOROPHENYLACETIC ACID
• 3-Fluoro-4-Bromoobenzyl Cyanide
• 4-Bromo-2,6-dimethylaniline
• 4-Bromo-3-fluorobenzonitrile
• 4-Bromo-2-chlorobenzonitrile
• 4-Bromo-3-methylphenol
• 4-BROMO-2-METHYLANISOLE
• 4-Bromo-2-fluorobenzotrifluoride
• 4-Bromo-2-methyl-benzaldehyde