Basic information Safety Supplier Related

(-)-BICUCULLINE METHOBROMIDE

Basic information Safety Supplier Related

(-)-BICUCULLINE METHOBROMIDE Basic information

Product Name:
(-)-BICUCULLINE METHOBROMIDE
Synonyms:
  • [R-(R*,S*)]-5-(6,8-DIHYDRO-8-OXOFURO[3,4-E]-1,3-BENZODIOXOL-6-YL)-5,6,7,8-TETRAHYDRO-6,6-DIMETHYL-1,3-DIOXOLO[4,5-G]ISOQUINDINIUM BROMIDE
  • [R-(R*,S*)]-5-(6,8-DIHYDRO-8-OXOFURO[3,4-E]-1,3-BENZODIOXOL-6-YL)-5,6,7,8-TETRAHYDRO-6,6-DIMETHYL-1,3-DIOXOLO[4,5-G]ISOQUINOLINIUM BROMIDE
  • (-)-BICUCULLINE 1(S),9(R) METHBROMIDE
  • (-)-BICUCULLINE METHOBROMIDE
  • Bicuculineracemic
  • (R-(R*,S*))-5-(6,8-Dihydro-8-oxofuro[3.4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4.5-g]isoq
  • Bicuculinemethoiodide
  • [R-(R,S)]-5-(6,8-Dihydro-8-oxofuro[3,4-e]-1,3-benzodioxol-6-yl)-5,6,7,8-tetrahydro-6,6-dimethyl-1,3-dioxolo[4,5-g]isoquinolinium bromide
CAS:
73604-30-5
MF:
C21H20NO6.Br
MW:
462.29
Product Categories:
  • GABA
  • GABA/Glycine receptor
Mol File:
73604-30-5.mol
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(-)-BICUCULLINE METHOBROMIDE Chemical Properties

storage temp. 
2-8°C
solubility 
aqueous base: unstable
form 
solid
color 
white
Water Solubility 
Soluble in water (50mM)
Sensitive 
Light Sensitive
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Safety Information

Safety Statements 
24/25
RIDADR 
UN 1544 6.1/PG 2
WGK Germany 
3
HazardClass 
6.1(b)
PackingGroup 
III

MSDS

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(-)-BICUCULLINE METHOBROMIDE Usage And Synthesis

Uses

(-)-Bicuculline methobromide is an N-methylated derivative of the GABAA?antagonist bicuculline.

Biological Activity

Methobromide salt of (+)-bicuculline ([R-(R*,S*)]-6-(5,6,7,8-Tetrahydro-6-methyl-1,3-dioxolo[4,5-g]isoquinolin-5-yl)furo[3,4-e]-1,3-benzodioxol-8(6H)-one ). Water soluble and more stable than bicuculline. Non-GABA receptor-mediated actions reported.

in vivo

(-)-Bicuculline methobromide can be used in animal modeling to create epilepsy models and is capable of crossing the blood-brain barrier[3].

1. Induction of epilepsy[3]
Background
(-)-Bisculline methoromide can inhibit the synthesis and release of GABA, and weaken GABA's inhibition of neuronal activity in the SN reticular region (SNr), leading to epilepsy.
Specific Mmodeling Methods
Rat: Sprague-Dawley (SD) ? male or female ? 2 weeks old
Administration: 12.5, 25, 50 or 100 ng/0.25 μL ? inject into SN or corpus striatum through bilateral catheter implantation
Note
(1) Dissolve (-)-Bicuculine methoromide in distilled water and administer at a volume of 0.25 μL.
(2) Simultaneously administer bilateral infusions at a rate of 0.25 μ L/min, and after the infusion is completed, insert the catheter in situ for an additional minute to prevent drug reflux.
(3) Due to the short-lived effect of (-) - Bicuculine methoromide in SN, rats were tested 5 minutes after completing the infusion.
Modeling Indicators
Behavioral observation: Shortened the latency period of epileptic seizures, causing stereotyped behaviors such as excessive sniffing or licking, chewing movements, head twitching, and slow or occasional circling.
Correlated Product(s): Muscimol (HY-N2313)
Opposite Product(s): /

Animal Model:Rat L5-SNL model[2]
Dosage:0.6 nmol/rat
Administration:Intrathecal injection, 5 minutes before administration of Neurotropin (100 NU/kg, i.v.)
Result:Attenuated the antiallodynic effect of Neurotropin.

storage

Room temperature

(-)-BICUCULLINE METHOBROMIDESupplier

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