PARAOXON Chemical Properties

Melting point:

300°C

Boiling point:

169-170°C

Density 

1.274 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.51(lit.)

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

form 

oil

color 

yellow

Odor

slt odor

Water Solubility 

3.627g/L(20 ºC)

Merck 

13,7102

BRN 

1915526

Stability:

Moisture Sensitive

CAS DataBase Reference

311-45-5

EPA Substance Registry System

Paraoxon (311-45-5)

Safety Information

Hazard Codes 

T+,N

Risk Statements 

26/27/28-50

Safety Statements 

36/37/39-45-61

RIDADR 

UN 2810 6.1/PG 1

WGK Germany 

3

RTECS 

TC2275000

HazardClass 

6.1(a)

PackingGroup 

I

Hazardous Substances Data

311-45-5(Hazardous Substances Data)

Toxicity

LD50 orally in rats: 1.8 mg/kg (Pickering, Malone)

MSDS

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PARAOXON Usage And Synthesis

Chemical Properties

Oily Liquid

Chemical Properties

Paraoxon is an odorless, reddish-yellow oil. Fruity odor.

Uses

A cholinesterase inhibitor

Uses

Paraoxon-ethyl has been used as a substrate?in paraoxonase (PON) activity assay. It has also been used as a lipase inhibitor to study the effects of anacetrapib on homotypic transfer from high density lipoprotein?L3 (HDL3)?to?HDL2?in vivo.

Uses

Insecticide.

Definition

ChEBI: An aryl dialkyl phosphate where both the alkyl groups are ethyl and the aryl group is 4-nitrophenyl.

Synthesis Reference(s)

Tetrahedron Letters, 31, p. 3359, 1990 DOI: 10.1016/S0040-4039(00)89065-6

General Description

Reddish-yellow oily liquid with a faint fruity odor.

Reactivity Profile

Organophosphates are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

Fire Hazard

Flash point data for PARAOXON are not available; however, PARAOXON is probably combustible.

Biochem/physiol Actions

Potent irreversible acetylcholinesterase inhibitor

Safety Profile

A deadly poison by ingestion,intraperitoneal, intravenous, subcutaneous, intramuscular,and parenteral routes. Mutation data reported. Humansystemic effects: coma, convulsions, miosis. Acholinesterase inhibitor. An insecticide. When heated todecompos

Potential Exposure

An organophosphate insecticide. Has been used as a medication.

Shipping

UN3018 Organophosphorus pesticides, liquid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.

Incompatibilities

Keep away from alkaline materials and strong oxidizers. Contact with oxidizers can cause the release of toxic oxides of phosphorus. May react violently with antimony(V) pentafluoride. Incompatible with lead diacetate, magnesium, silver nitrate. In the presence of strong reducing agents such as hydrides, organophosphates form highly toxic and flammable phosphine gas.

Waste Disposal

In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

PARAOXON(311-45-5)Related Product Information

• Trimethyl phosphite
• DIMETHYL PHOSPHATE
• Diethyl phosphite
• DIETHYL PHOSPHATE
• PHENYLPHOSPHORIC ACID
• 4-Nitrosophenol
• METHYL PARAOXON,PARAOXON-METHYL,Dimethyl paraoxon,PARAOXON-METHYL PESTANAL, > 96%,O,O-Dimethyl O-(4-nitrophenyl) phosphate, Paraoxon-methyl
• TRI-AMMONIUM PHOSPHATE TRIHYDRATE
• Dimethyl phosphite
• PARAOXON
• Trimethyl phosphate
• Parathion
• 4-(4-NITROPHENYL)MORPHOLINE
• ETHYLPHOSPHONIC ACID
• 6-Carboxyhexylphosphocholine p-Nitrophenyl Ester
• DIETHYLMETHYLPHOSPHATE
• DIMETHYLETHYLPHOSPHATE
• Bis(3-chloropropyl) p-nitrophenyl phosphate