Basic information Safety Supplier Related

LITHIUM DICYCLOHEXYLAMIDE

Basic information Safety Supplier Related

LITHIUM DICYCLOHEXYLAMIDE Basic information

Product Name:
LITHIUM DICYCLOHEXYLAMIDE
Synonyms:
  • N-Lithiodicyclohexylamine
  • LITHIUM DICYCLOHEXYLAMIDE
  • (Dicyclohexylamino)lithium
  • Lithiodicyclohexylamine
  • N-Lithiobis(cyclohexyl)amine
  • LiN(Cy)2
  • lithium,dicyclohexylazanide
  • ithium dicycL
CAS:
4111-55-1
MF:
C12H22LiN
MW:
187.25
EINECS:
223-894-6
Product Categories:
  • Chemical Synthesis
  • Organic Bases
  • Synthetic Reagents
Mol File:
4111-55-1.mol
More
Less

LITHIUM DICYCLOHEXYLAMIDE Chemical Properties

solubility 
Partially soluble in benzene and hexanes; soluble in THF.
More
Less

Safety Information

Hazard Codes 
F,C
Risk Statements 
17-34
Safety Statements 
16-26-27-36/37/39-45
RIDADR 
UN 3393 4.2/PG 1
WGK Germany 
3
HazardClass 
4.2
PackingGroup 
I

MSDS

More
Less

LITHIUM DICYCLOHEXYLAMIDE Usage And Synthesis

Uses

Lithium Dicyclohexylamide is used in processes for preparing 2-Dihalo-ribolactones as synthons for antiviral nucleosides via coupling reaction.

Reactivity Profile

Lithium Dicyclohexylamide performs as a strong base, allowing deprotonation of ketones, esters, aryl and allyl halides, alkyl dihalides, allenes, alkyl boron reagents, azulene and methylazulenes; used for the formation of formamides, glyoxylamides, oxomalonamides, and tartronamides.

Synthesis

Lithium Dicyclohexylamide could be prepared from the reaction of dicyclohexylamine with n-Butyllithium in hexanes and benzene at 0 °C; the solvent can then be removed under reduced pressure, and the resulting free-flowing solid can be dissolved in THF.
Both solution and solid are pyrophoric and air- and moisture-sensitive; also, the solid is spontaneously flammable in air. The reagent is corrosive and extremely destructive to tissues of the mucous membranes and the upper respiratory tract, eyes, and skin. Note that dicyclohexylamine is a suspected carcinogen and may cause chemical pneumonitis and pulmonary edema. Use in a fume hood.

References

1. Wilson, J. W.; Pelter, A.; Garad, M. V.; Pardasani, R. T 1993, 49, 2979.
2. Aldrich Chemical Co.; Material Safety Data Sheet.
3. Furlong, J. J. P.; Lewkowicz, E. S.; Nudelman, N. S. JCS(P2) 1990, 1461.

LITHIUM DICYCLOHEXYLAMIDESupplier

Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Email
sales.bj@hwrkchemical.com
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Email
2355560935@qq.com
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418671 +8618949823763
Email
sales@tnjchem.com
Shanghai Sunway Pharmaceutical Technology Co.,Ltd.
Tel
021-51816796-820 13611835272
Email
sales2@sunwaypharm.com
Aikon International Limited
Tel
18626450290
Email
yftan@aikonchem.com