Basic information Description References Safety Supplier Related
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Menatetrenone

Basic information Description References Safety Supplier Related

Menatetrenone Basic information

Product Name:
Menatetrenone
Synonyms:
  • MENATETRENONE
  • MENAQUINONE 4
  • MENAQUINONE
  • 1,4-naphthoquinone,2-methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraen
  • 2-methyl-3-(3,7,11,15-tetramethyl-2,6,10,14-hexadecatetraenyl)-1,4-naphthoqu
  • 2-methyl-3-trans-tetraprenyl-1,4-naphthoquinone
  • e3100
  • k2(sub20)
CAS:
863-61-6
MF:
C31H40O2
MW:
444.65
Product Categories:
  • Osteoporosis
  • Intermediates & Fine Chemicals
  • Vitamins and derivatives
  • Pharmaceuticals
  • Aromatics
Mol File:
863-61-6.mol
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Menatetrenone Chemical Properties

Melting point:
350C
Boiling point:
494.59°C (rough estimate)
Density 
1.0461 (rough estimate)
refractive index 
1.5045 (estimate)
Flash point:
2℃
storage temp. 
-20°C
form 
neat
InChIKey
DKHGMERMDICWDU-GHDNBGIDSA-N
CAS DataBase Reference
863-61-6(CAS DataBase Reference)
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Safety Information

Safety Statements 
22-24/25
RIDADR 
UN 1648 3 / PGII
WGK Germany 
3
RTECS 
QL9279500
HS Code 
2914699000
Toxicity
LD50 intravenous in dog: > 40mL/kg

MSDS

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Menatetrenone Usage And Synthesis

Description

Menatetrenone (also known as MK-4) is a manaquinone compound and a vitamin K compound which can be used as a hemostatic agent as well as adjunctive therapy for the pain of osteoporosis. It mainly takes effects through modulating the signaling of certain tyrosine kinases, thereby affecting several transcription factors including c-myc and c-fos. It is capable of inhibiting tumor cells growth through inducing apoptosis and cell cycle arrest. It can be produced via the conversion of vitamin K1 inside the body including the testes, pancreas and arterial walls.

References

https://pubchem.ncbi.nlm.nih.gov/compound/menatetrenone#section=Biomolecular-Interactions-and-Pathways
https://en.wikipedia.org/wiki/Menatetrenone

Chemical Properties

Yellow Crystals

Uses

Vitamin (prothrombogenic)

Uses

Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a vari ety of physiological processes. Menaquinone 4 has four isoprene residue in its side chain and is also commonly refered to as menatetrenone. Menaquinone-4 is the most common type of vitamin K2 and is k nown as a hemostatic agent and is used as adjunctive therapy for the pain of osteoporosis.

Uses

Menaquinones are isoprenoid quinones of the naphthalene series and belongs to the K2 Vitamin homologs. Menaquinones were originally discovered as the anti-hemorrhagic factor and now encompasses a variety of physiological processes. Menaquinone 4 has four isoprene residue in its side chain and is also commonly refered to as menatetrenone. Menaquinone-4 is the most common type of vitamin K2 and is known as a hemostatic agent and is used as adjunctive therapy for the pain of osteoporosis.

Definition

ChEBI: A menaquinone whose side-chain contains 4 isoprene units in an all-trans-configuration.

General Description

Menaquinone (K2), a vitamin K2 homologue with four isoprene units. It has been reported to enhance bone formation and plays a vital role in the production of blood coagulation factors.

Biochem/physiol Actions

Menatetrenone (MK-4) is one of nine forms of vitamin K2 which is ubiquitously present in extrahepatic tissues. MK-4 has a number of metabolic and anti-neoplastic activities.

MenatetrenoneSupplier

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