(+/-)-BAY K 8644 Chemical Properties

Melting point:

166-172 °C

storage temp. 

2-8°C

solubility 

DMSO: 184 mg/mL

form 

Yellow solid

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/38

Safety Statements 

26-36

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

(+/-)-BAY K 8644 Usage And Synthesis

Definition

ChEBI: Methyl 2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate is a pentasubstituted dihydropyridine carrying methoxycarbonyl, 2-(trifluoromethyl)phenyl and nitro substituents at positions 3, 4 and 5 respectively as well as two methyl substituents at positions 2 and 6. It is a dihydropyridine, a methyl ester, a C-nitro compound and a member of (trifluoromethyl)benzenes.

General Description

Synthetic dihydropyridine derivative that acts as an active Ca²⁺ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca²⁺ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive inotropic, and Ca²⁺ agonistic properties, whereas the (+)-enantiomer has weakly vasodilating, negative inotropic, and Ca²⁺ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Promotes β-cell proliferation/regeneration.

Biochem/physiol Actions

Primary TargetL-type Ca2+ channel

(+/-)-BAY K 8644(93468-89-4)Related Product Information

• (+/-) CAGED BAY K 8644
• R(+)-BAY K 8644, CALCIUM CHANNEL
• R(+)-BAY K 8644,R(+)-BAY K 8644 CA2(+) CHANNEL BLOCKE,(+/-)-BAY K 8644, 0 TO 5 °C,R(+)-BAY K 8644 98% 0 C
• S(-)-BAY K 8644,S(-)-BAY K 8644 CA2+ CHANNEL ACTIVATO
• R(+)-BAY K 8644 CALCIUM CHANNEL
• (RS)-BAY K 8644,(+/-)-BAY K 8644,BAY K-8644 (+/-),(+/-)-BAY K8644 CALCIUM SLOW CHANNEL
• (+-)-CAGED BAY K 8644