HNRNP M ANTIBODY Usage And Synthesis

Source

Rabbit

Reactivity

Human

Background

Heterogenous nuclear ribonucleoprotein M belongs to a family of RNA-binding multi-protein complexes that facilitate pre-mRNA processing. hnRNP M binds to GU rich regions of RNA and exists as 4 isoforms named M1-M4. Binding to pre-mRNA in early stages of spliceosome assembly, hnRNP M contributes to splicing events by inducing exon skipping as well as promoting exon inclusion. hnRNP M is expressed on the surface of Kupffer cells, and acts as a receptor for carcinoembryonic antigen, a biomarker for colorectal cancer metastasis to the liver. hnRNP M has also shown to be a key regulator of the innate immune response in macrophages, where it represses key inflammatory and antimicrobial genes.

References

[1] Dreyfuss, G. et al. (1993) Annu Rev Biochem 62, 289-321.
[2] Datar, K.V. et al. (1993) Nucleic Acids Res 21, 439-46.
[3] Kafasla, P. et al. (2002) Biochem J 363, 793-9.
[4] Hovhannisyan, R.H. and Carstens, R.P. (2007) J Biol Chem 282, 36265-74.
[5] Bajenova, O. et al. (2003) Exp Cell Res 291, 228-41.
[6] Laguinge, L. et al. Anticancer Res 25, 23-31.
[7] Thomas, P. et al. (2011) Clin Exp Metastasis 28, 923-32.
[8] Cao, P. et al. (2019) PLoS Pathog 15, e1007983.
[9] West, K.O. et al. (2019) Cell Rep 29, 1594-1609.e5.

HNRNP M ANTIBODY()Related Product Information

• CACNA1A antibody
• Rabbit Polyclonal ZWILCH Antibody
• FDFT1 antibody
• SLC16A11 antibody
• SORT1 antibody
• PTGIS antibody
• DTX3L ANTIBODY
• TPD52L1 Antibody
• LGALS8 antibody
• GAGE12I antibody