5-BROMOPYRIDINE-2-CARBONYL CHLORIDE Chemical Properties

Boiling point:

250 ºC

Density 

1.760

Flash point:

105 ºC

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

Solid

pka

-1.86±0.10(Predicted)

Sensitive 

Moisture Sensitive

Safety Information

HazardClass 

IRRITANT

HazardClass 

8

HS Code 

29333990

5-BROMOPYRIDINE-2-CARBONYL CHLORIDE Usage And Synthesis

Chemical Properties

Brown solid

Synthesis

General procedure for the synthesis of 5-bromo-pyridine-2-carbonyl chloride from 2-carboxylic acid-5-bromopyridine: To a solution of dichloromethane (80 mL) containing 5-bromo-pyridine-2-carboxylic acid (0.05 mmol), oxalyl chloride (0.24 mmol) and N,N-dimethylformamide (5 drops) were slowly added dropwise at room temperature. The reaction mixture was stirred at room temperature for 2 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure to give 5.4 g (100% yield) of 5-bromo-pyridine-2-carbonyl chloride.

References

[1] Patent: CN103130792, 2016, B. Location in patent: Paragraph 0533
[2] Patent: WO2014/164749, 2014, A1. Location in patent: Page/Page column 312
[3] Patent: WO2017/221100, 2017, A1. Location in patent: Paragraph 00262
[4] Tetrahedron, 2005, vol. 61, # 45, p. 10748 - 10756
[5] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 7, p. 2074 - 2079

5-BROMOPYRIDINE-2-CARBONYL CHLORIDE(137178-88-2)Related Product Information

• Ammonium chloride
• Choline chloride
• Benzoyl chloride
• 2,3,4,5-Tetrafluorobenzoyl chloride
• Calcium chloride
• PYRAZOPHOS
• Methylaminoformyl chloride
• 5-Bromo-2-methylpyridine
• Sodium chloride
• Polyvinyl chloride
• 1-Hexadecylpyridinium bromide
• o-Toluoyl chloride
• CARBONYL SULFIDE
• Potassium chloride
• 4-Nitrobenzoyl chloride
• 5-Bromopyridine-2-carbaldehyde
• Methanesulfonyl chloride
• Methylene Chloride