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Pomalidomide-PEG1-azide

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Pomalidomide-PEG1-azide Basic information

Product Name:
Pomalidomide-PEG1-azide
Synonyms:
  • Pomalidomide-PEG1-azide
  • Pomalidomide-NH-CO-PEG1-N3
  • 2-(2-Azidoethoxy)-N-[2-(2,6-dioxo-3-piperidyl)-1,3-dioxoisoindolin-4-yl]acetamide
  • N3-PEG1-CH2CO-Poma
  • Acetamide, 2-(2-azidoethoxy)-N-[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]-
CAS:
2133360-04-8
MF:
C17H16N6O6
MW:
400.35
Product Categories:
  • peg
Mol File:
2133360-04-8.mol
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Pomalidomide-PEG1-azide Chemical Properties

storage temp. 
2-8°C
solubility 
DMSO : 62.5 mg/mL (156.11 mM; ultrasonic and warming and heat to 60°C)
form 
Solid
color 
Light yellow to yellow
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Pomalidomide-PEG1-azide Usage And Synthesis

Uses

Protein degrader builiding block Pomalidomide-PEG1-azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

Pomalidomide-PEG1-azideSupplier

Sigma-Aldrich
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