Sitagliptin Impurity 12 Chemical Properties

Boiling point:

517.5±60.0 °C(Predicted)

Density 

1.52±0.1 g/cm3(Predicted)

solubility 

soluble in Chloroform, DCM, Methanol

pka

-0.06±0.20(Predicted)

form 

Oil

color 

Light Yellow

Sitagliptin Impurity 12 Usage And Synthesis

Uses

(2Z)-1-[5,6-Dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-2-buten-1-one is an intermediate in the synthesis of 3-Desamino-2,3-dehydro Sitagliptin (D281985),an impurity of Sitagliptin (S491000). Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes.

Sitagliptin Impurity 12(1803026-54-1)Related Product Information

• Sitagliptin Impurity 28
• Sitagliptin Impurity 46
• Sitagliptin Impurity 77
• Sitagliptin impurity 5
• Methyl 3-aMino-4-(2,4,5-trifluorophenyl)butanoate
• ethyl 3-oxo-4-(2,4,5-trifluorophenyl)butanoate
• 2-CHLOROMETHYL-5-TRIFLUOROMETHYL-[1,3,4]OXADIAZOLE
• Sitagliptin Impurity 34
• 2,4,5-TRIFLUOROBENZYL CHLORIDE
• (R)-methyl 3-acetamido-4-(2,4,5-trifluorophenyl)butanoate
• Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,Methylester,(bR)-
• Sitagliptin
• Sitagliptin Impurity 14
• Sitagliptin Defuoro IMpurity 5
• Sitagliptin DeaMino IMpurity 1
• (S)-Sitagliptin Phosphate
• 2,2,2-TRIFLUORO-N'-(TRIFLUOROACETYL)ACETOHYDRAZIDE
• (R)-10-(2,4,5-trifluorobenzyl)-3-(trifluoromethyl)-6,7,10,11-tetrahydro-[1,2,4]triazolo[3,4-c][1,4,7]triazecine-8,12(5H,9H)-dione