Basic information Safety Supplier Related
ChemicalBook >  Product Catalog >  API >  Antibiotics >  Other antibiotic Drugs >  STAUROSPORINE

STAUROSPORINE

Basic information Safety Supplier Related

STAUROSPORINE Basic information

Product Name:
STAUROSPORINE
Synonyms:
  • CS-2206
  • Staurosporineinsolution
  • 9,13-Epoxy-1H,9H-diindolo1,2,3-gh:3,2,1-lmpyrrolo3,4-j1,7benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S,10R,11R,13R)-
  • Staurosporine, Antibiotic AM-2282
  • (9S,10R,11R,13R)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one
  • AM-2282
  • Antibiotic 230
  • CGP 39360
CAS:
62996-74-1
MF:
C28H26N4O3
MW:
466.54
EINECS:
613-127-7
Product Categories:
  • Inhibitor
  • All Inhibitors
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Signalling
  • Protein Kinase Inhibitors and Activators
  • Protein Kinase
  • antibiotic
  • API
Mol File:
62996-74-1.mol
More
Less

STAUROSPORINE Chemical Properties

Melting point:
270°C
alpha 
D25 +35.0° (c = 1 in methanol); D22 +56.1° (c = 0.14 in methanol)
Boiling point:
677.5±55.0 °C(Predicted)
Density 
1.56±0.1 g/cm3(Predicted)
RTECS 
KD5084000
storage temp. 
2-8°C
solubility 
DMSO: soluble
form 
White to pale yellow solid
pka
14.25±0.70(Predicted)
color 
Off white to pale yellow
Water Solubility 
Soluble in DMSO or ethanol.Soluble in dimethyl sulfoxide , dimethyl formamide, ethyl acetate, hot acetone and ethanol. Slightly soluble in chloroform and methanol. Insoluble in water.
BRN 
1060573
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 4 months.
InChIKey
HKSZLNNOFSGOKW-WIFUGMKFSA-N
CAS DataBase Reference
62996-74-1
More
Less

Safety Information

Hazard Codes 
Xn,T,Xi
Risk Statements 
40-45-36/37/38-46
Safety Statements 
36/37-53-36-26-45
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
2
8-10
HazardClass 
3
HS Code 
29419090

MSDS

More
Less

STAUROSPORINE Usage And Synthesis

Description

Staurosporine (Stsp) is potent inhibitor of protein kinase C (PKC) from rat brain, exhibiting an IC50 value of 2.7 nM. It inhibits rat recombinant PKC-α approximately 100- and 1,000-fold better than PKC-δ and PKC-ζ, respectively. However, Stsp is non-selective in that it also inhibits the activity of a variety of other protein kinases, not only PKC isoforms. The biological effects of Stsp include cytotoxicity, relaxation of smooth muscle, and regulation of eNOS gene expression.

Chemical Properties

Light Yellow Solid

Occurrence

A complex alkaloid. staurosporine has been isolated from a strain of Streptomyces.

Uses

Staurosporine is an unusual indolocarbazole alkaloid produced by a range of actinomycete species. It is a potent antitumour active, inducing apoptosis in a variety of cell lines. Staurosporine is a potent inhibitor of many kinases including protein kinase C, tyrosine kinase, CDK2/cyclin A and CDK4/cyclin D. At submicromolar concentrations, staurosporine inhibits both IKKalpha and IKKbeta.

Uses

Staurosporine is a protein Kinase C inhibitor that induces apoptosis in many cell types.

Definition

ChEBI: Staurosporine is an indolocarbazole alkaloid and an organic heterooctacyclic compound. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor, a geroprotector, a bacterial metabolite and an apoptosis inducer. It is a conjugate base of a staurosporinium.

General Description

A potent, cell-permeable, reversible, ATP-competitive and broad spectrum inhibitor of protein kinases. Inhibits CaM kinase (IC50 = 20 nM), myosin light chain kinase (IC50 = 1.3 nM), protein kinase A (IC50 = 7 nM), protein kinase C (IC50 = 0.7 nM), and protein kinase G (IC50 = 8.5 nM). Also inhibits platelet aggregation induced by collagen or ADP but has no effect on thrombin-induced platelet aggregation. Induces apoptosis in human malignant glioma cell lines. Arrests normal cells at the G1 checkpoint.

Biological Activity

Broad spectrum protein kinase inhibitor. Enzymes inhibited include protein kinase C (IC 50 = 3 nM), protein kinase A (IC 50 = 7 nM), p 60v-src tyrosine protein kinase (IC 50 = 6 nM) and CaM kinase II (IC 50 = 20 nM). Also available as part of the Mixed Kinase Inhibitor Tocriset™ .

Biochem/physiol Actions

Reversible: yes

storage

+4°C

References

1) Omura et al. (1977) A new alkaloid AM-2282 of Streptomyces origin taxonomy, fermentation, isolation and preliminary characterization; J. Antibiot., 30 275 2) Ruegg and Burgess (1989) Staurosporine, K-252 and UCN-01: potent but nonspecific inhibitors of protein kinases; Trends in Pharmacological Science 10 218

STAUROSPORINESupplier

Shanghai Hanjing Chemicals Co., Ltd. Gold
Tel
021-54285032 13641685631
Email
gerry.shu@hanjingchemicals.com
Wuxi enqiao Pharmaceutical Technology Co., Ltd Gold
Tel
0510-83591909 18018392058
Email
info@enbridgepharm.com
Fujian Kerui Pharmaceutical Co., Ltd. Gold
Tel
+86-591-83309157; 18505919179
Email
23115188@qq.com
Hubei widely chemical technology Co., Ltd. Gold
Tel
027-59402396 13419635609
Email
13419635609@163.com
Huzhou fuhe Rui biological medicine co., ltd Gold
Tel
13626726938
Email
953022190@qq.com