PROGUANIL HYDROCHLORIDE
PROGUANIL HYDROCHLORIDE Basic information
- Product Name:
- PROGUANIL HYDROCHLORIDE
- Synonyms:
-
- PROGUANIL HYDROCHLORIDE
- (1E)-1-[amino-(3,4-dichloroanilino)methylidene]-2-propan-2-ylguanidine
- 1-carbamimidoyl-1-(3,4-dichlorophenyl)-2-propan-2-yl-guanidine hydroch loride
- N-(3,4-Dichlorophenyl)-N'-(1-Methylethyl)iMidodicarboniMidic DiaMide
- N1-3,4-Dichlorophenyl-N5-isopropyldiguanide
- Chloroproguanil
- 1-(3,4-Dichlorophenyl)-5-isopropylbiguanide
- Imidodicarbonimidic diamide, N-(3,4-dichlorophenyl)-N'-(1-methylethyl)-
- CAS:
- 537-21-3
- MF:
- C11H15Cl2N5
- MW:
- 288.18
- EINECS:
- 208-660-3
- Product Categories:
-
- Amines
- Aromatics
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Mol File:
- 537-21-3.mol
PROGUANIL HYDROCHLORIDE Chemical Properties
- Melting point:
- 120-121 °C
- Boiling point:
- 350.7±52.0 °C(Predicted)
- Density
- 1.40±0.1 g/cm3(Predicted)
- solubility
- DMSO (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 10.77±0.10(Predicted)
- color
- White to Off-White
- BCS Class
- 1
- Stability:
- Hygroscopic
PROGUANIL HYDROCHLORIDE Usage And Synthesis
Uses
PROGUANIL HYDROCHLORIDE is an antimalarial agent used in combination with Dapsone (D193250).
Definition
ChEBI: Chlorproguanil is a dichlorobenzene.
Clinical Use
Malaria chemoprophylaxis
Drug interactions
Potentially hazardous interactions with other drugs
Anticoagulants: effect of warfarin possibly enhanced.
Antimalarials: avoid concomitant use with
artemether/lumefantrine; increased antifolate effect
with pyrimethamine.
Metabolism
Proguanil is metabolised in the liver to the active metabolite, cycloguanil, and to p-chlorophenylbiguanide which is inactive, mainly by cytochrome P450, CYP 2C19 and slightly by CYP 3A4. Unlike proguanil and p-chlorophenylbiguanide, cycloguanil is not concentrated in erythrocytes so concentrations of cycloguanil in plasma and whole blood are similar. About 40-60% of a dose of proguanil is excreted in the urine, 60% of this as the unchanged drug, 30% as cycloguanil, and 8% as p-chlorophenylbiguanide. About 10% of a dose is excreted in the faeces.
PROGUANIL HYDROCHLORIDESupplier
- Tel
- 010-82848833 400-666-7788
- jkinfo@jkchemical.com
- Tel
- 021-50135380
- shchemsky@sina.com
- Tel
- +86-400-002-6226 +86-13028896684;
- sales@rrkchem.com
- Tel
- 021-58432009 400-005-6266
- marketing@energy-chemical.com
- Tel
- 029-61856358 15229202216
- 1020@dideu.com
PROGUANIL HYDROCHLORIDE(537-21-3)Related Product Information
- Verapamil
- N-(4-CHLOROPHENYL)-N'-(ISOPROPYL)-IMIDODICARBONIMIDIC DIAMIDE
- 1-(4-CHLOROPHENYL)BIGUANIDE HYDROCHLORIDE
- 3-Chlorophenylguanidine
- 1-(3-CHLOROPHENYL)BIGUANIDE HYDROCHLORIDE
- 4-CHLOROPHENYLGUANIDINE HYDROCHLORIDE
- Chlorguanide Hydrochloride
- N-(3,4-Dichlorophenyl)guanidine
- PROGUANIL HYDROCHLORIDE