4-Fluoroanisole Chemical Properties

Melting point:

−45 °C(lit.)

Boiling point:

157 °C(lit.)

Density 

1.114 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.488(lit.)

Flash point:

110 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Chloroform (Sparingly), Methanol (Slightly)

form 

Liquid

Specific Gravity

1.114

color 

Clear colorless to light yellow

Water Solubility 

Not miscible or difficult to mix in water.

BRN 

1281425

InChIKey

VIPWUFMFHBIKQI-UHFFFAOYSA-N

CAS DataBase Reference

459-60-9(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, 1-fluoro-4-methoxy-(459-60-9)

EPA Substance Registry System

p-Fluoroanisole (459-60-9)

Safety Information

Hazard Codes 

F

Risk Statements 

10

Safety Statements 

16

RIDADR 

UN 3271 3/PG 3

WGK Germany 

3

Hazard Note 

Flammable

TSCA 

T

HazardClass 

3

PackingGroup 

III

HS Code 

29093090

MSDS

• Language:English Provider:1-Fluoro-4-methoxybenzene
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

4-Fluoroanisole Usage And Synthesis

Synthesis

Fluorine itself reacts with a 4-substituted methoxy benzene tin derivative to give 4-fluoroanisole.

Chemical Properties

Colorless to light yellow liquid

Uses

An Acetanilide and Anisole derivative metabolite by liver.

Uses

4-Fluoroanisole is a raw material for medicine and intermediate.

Synthesis Reference(s)

The Journal of Organic Chemistry, 51, p. 1886, 1986 DOI: 10.1021/jo00360a042

4-Fluoroanisole(459-60-9)Related Product Information

• 1,2-Difluorobenzene
• 4-Fluorobenzoic acid
• Anisole
• 4-Bromofluorobenzene
• 4-Fluorobenzaldehyde
• Florfenicol
• Transfluthrin
• 4-Fluorobenzyl alcohol
• 4-Fluoroacetophenone
• 4-Fluorophenylacetic acid
• 4-Fluorophenylacetyl chloride
• Fluorine
• 3-Fluoroanisole 99%
• 3,5-Difluoroanisole
• 3-BROMO-2-FLUOROANISOLE
• 2-BROMO-4-CHLORO-6-FLUOROANISOLE
• 2,3-Difluoroanisole
• 4-AMINO-2,6-FLUOROANISOLE