1-BROMO-4-METHOXY-2,3-DIFLUOROBENZENE Chemical Properties

Melting point:

56-58°

Boiling point:

203.2±35.0 °C(Predicted)

Density 

1.615

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

Appearance

White to off-white Solid

Safety Information

Hazard Codes 

Xi

Hazard Note 

Irritant

HS Code 

2909309090

1-BROMO-4-METHOXY-2,3-DIFLUOROBENZENE Usage And Synthesis

Synthesis

General procedure: iodomethane (1.56 mL, 25.1 mmol, 1.5 eq.) was slowly added dropwise to a suspension of 2,3-difluoro-4-bromophenol (3.5 g, 16.7 mmol) and potassium carbonate (2.77 g, 20.0 mmol, 1.2 eq.) in N,N-dimethylformamide (30 mL). The reaction mixture was stirred at room temperature for 3 days. After completion of the reaction, the insoluble precipitate was removed by filtration. The filtrate was concentrated to dryness under reduced pressure. Dichloromethane and water were added to the residue and the product was extracted with dichloromethane. The organic phases were combined, dried over anhydrous magnesium sulfate and subsequently concentrated under reduced pressure to afford 4-bromo-2,3-difluoroanisole as a white crystalline solid (3.8 g, quantitative yield).

References

[1] Patent: WO2012/175991, 2012, A1. Location in patent: Page/Page column 78

1-BROMO-4-METHOXY-2,3-DIFLUOROBENZENE(406482-22-2)Related Product Information

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