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(S)-Amlodipine

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(S)-Amlodipine Basic information

Product Name:
(S)-Amlodipine
Synonyms:
  • 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (4S)-
  • 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, (S)-
  • l-Amlodipine
  • (S)-Amlodipine
  • Levamlodipine
  • (4S)-
  • Levoamlodipine Besylate
  • (4S)-2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester
CAS:
103129-82-4
MF:
C20H25ClN2O5
MW:
408.88
EINECS:
1592732-453-0
Product Categories:
  • 11
  • API
  • Pharmaceutical material and intermeidates
  • Amines
  • Chiral Reagents
  • Dihydropyridine
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • 103129-82-4
Mol File:
103129-82-4.mol
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(S)-Amlodipine Chemical Properties

Melting point:
102-104°C
Boiling point:
527.2±50.0 °C(Predicted)
Density 
1.227
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
Chloroform (Sparingly), Methanol (Slightly)
form 
Solid
pka
8.97±0.10(Predicted)
color 
White to Off-White
InChI
InChI=1S/C20H25ClN2O5/c1-4-28-20(25)18-15(11-27-10-9-22)23-12(2)16(19(24)26-3)17(18)13-7-5-6-8-14(13)21/h5-8,17,23H,4,9-11,22H2,1-3H3/t17-/m0/s1
InChIKey
HTIQEAQVCYTUBX-KRWDZBQOSA-N
SMILES
C(C1=C(NC(=C([C@@H]1C1C=CC=CC=1Cl)C(=O)OC)C)COCCN)(=O)OCC
CAS DataBase Reference
103129-82-4(CAS DataBase Reference)
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(S)-Amlodipine Usage And Synthesis

Chemical Properties

White to Off-White Solid

Uses

(S)-Enantiomer of Amlodipine. A dihydropyridine calcium channel blocker; activity resides mainly in the (-)-isomer.

Uses

(S)-Enantiomer of Amlodipine (A633495). A dihydropyridine calcium channel blocker; activity resides mainly in the (-)-isomer.

Definition

ChEBI: (S)-amlodipine is the (4S)-enantiomer of amlodipine. It is an enantiomer of a (R)-amlodipine.

(S)-AmlodipineSupplier

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