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NAPHTHOQUINE PHOSPHATE

Basic information Safety Supplier Related

NAPHTHOQUINE PHOSPHATE Basic information

Product Name:
NAPHTHOQUINE PHOSPHATE
Synonyms:
  • NAPHTHOQUINE PHOSPHATE
  • Naphthalene phosphoric acid phenol quinoline
  • Naphathoquine Phosphate
  • 4-[(7-Chloro-4-quinolinyl)amino]-2-[[(tert-butyl)amino]methyl]-5,6,7,8-tetrahydro-1-naphthalenol phosphate
  • NAPHTHOQUINE PHOSPHATE USP/EP/BP
CAS:
173531-58-3
MF:
C24H31ClN3O5P
MW:
507.95
Mol File:
173531-58-3.mol
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NAPHTHOQUINE PHOSPHATE Chemical Properties

storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Soluble in DMSO
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NAPHTHOQUINE PHOSPHATE Usage And Synthesis

Biological Activity

malaria remains a disease of devastating global impact, killing more than 800,000 people every year-the vast majority being children under the age of 5. naphthoquine phosphate is a antimalarial drug developed in china.

in vitro

naphthoquine phosphate showed promising antimalaria acitivities against various p. falciparum strains. moreover, previoius study highlighted that naphthoquine did not lose potency when tested against chloroquine resistant strains [1].

in vivo

in an study aiming to investigate the antimalarial activity of naphthoquine phosphate combined with artemisinine against plasmodium knowlesi in rhesus monkey, it was found that the combination of naphthoquine phosphate and artemisinine was superior to the single component and the optimum proportion in the combination is 1 : 2.5 in treating p. knowlesi infection in monkeys [2].

IC 50

0.1-5.2 nm for various p. falciparum strains [1]

References

[1] delves m, plouffe d, scheurer c, meister s, wittlin s, winzeler ea, sinden re, leroy d. the activities of current antimalarial drugs on the life cycle stages of plasmodium: a comparative study with human and rodent parasites. plos med. 2012;9(2):e1001169.
[2] wang jy, ding db, li gf, zhao jh. therapeutic efficacy of naphthoquine phosphate combined with artemisinine against plasmodium knowlesi. zhongguo ji sheng chong xue yu ji sheng chong bing za zhi. 2008;26(6):442-4.
[3] tun t, tint hs, lin k, kyaw tt, myint mk, khaing w, tun zw. efficacy of oral single dose therapy with artemisinin-naphthoquine phosphate in uncomplicated falciparum malaria. acta trop. 2009;111(3):275-8.

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