GSK3145095 Chemical Properties

Density 

1.45±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMSO:164.5(Max Conc. mg/mL);413.96(Max Conc. mM)
Ethanol:6.0(Max Conc. mg/mL);15.1(Max Conc. mM)

form 

Solid

pka

8.82±0.40(Predicted)

color 

White to off-white

InChIKey

ATQAGKAMBISZQM-HNNXBMFYSA-N

SMILES

N1C(C(N[C@H]2CCC3=CC(F)=CC(F)=C3NC2=O)=O)=NC(CC2=CC=CC=C2)=N1

GSK3145095 Usage And Synthesis

Uses

GSK3145095 is a RIP1 kinase inhibitor with an IC50 of 6.3 nM [1].

References

[1] Harris PA, ET AL. Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer. ACS Med Chem Lett. 2019 May 9;10(6):857-862. DOI:10.1021/acsmedchemlett.9b00108

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