MD2-TLR4-IN-1 Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMSO: 83.33 mg/mL (197.80 mM)

form 

Solid

color 

White to off-white

MD2-TLR4-IN-1 Usage And Synthesis

Uses

MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively[1].

References

[1] Liu Z, et al. Discovery of 3-(Indol-5-yl)-indazole Derivatives as Novel Myeloid Differentiation Protein 2/Toll-like Receptor 4 Antagonists for Treatment of Acute Lung Injury. J Med Chem. 2019 Jun 13;62(11):5453-5469. DOI:10.1021/acs.jmedchem.9b00316

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