BI-3406
BI-3406 Basic information
- Product Name:
- BI-3406
- Synonyms:
-
- BI-3406
- SOS1-IN-2
- N-((R)-1-(3-Amino-5-(trifluoromethyl)phenyl)ethyl)-7-methoxy-2-methyl-6-(((S)-tetrahydrofuran-3-yl)oxy)quinazolin-4-amine
- 4-Quinazolinamine, N-[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]-7-methoxy-2-methyl-6-[[(3S)-tetrahydro-3-furanyl]oxy]-
- N-[(1R)-1-[3-Amino-5-(trifluoromethyl)phenyl]ethyl]-7-methoxy-2-methyl-6-[(3S)-oxolan-3-yl]oxyquinazolin-4-amine
- N-[(1R)-1-[3-Amino-5-
- KRAS,interaction,anticancer,Inhibitor,BI3406,BI 3406,inhibit,Son,Sevenless,GTP-loaded,BI-3406,Ras,p38 MAPK,orally,SOS1
- N-[(1R)-1-[3-amino-5-(trifluoromethyl)phenyl]ethyl]-7-methoxy-2-methyl-6-[(3S)-tetrahydrofuran-3-yl]oxy-quinazolin-4-amine
- CAS:
- 2230836-55-0
- MF:
- C23H25F3N4O3
- MW:
- 462.46
- Product Categories:
-
- APIs
- API
- Mol File:
- 2230836-55-0.mol
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BI-3406 Chemical Properties
- Boiling point:
- 534.5±50.0 °C(Predicted)
- Density
- 1.347±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:100.0(Max Conc. mg/mL);216.23(Max Conc. mM)
Ethanol:100.0(Max Conc. mg/mL);216.23(Max Conc. mM) - form
- A solid
- pka
- 6.58±0.70(Predicted)
- color
- White to off-white
- InChIKey
- XVFDNRYZXDHTHT-PXAZEXFGSA-N
- SMILES
- N1=C2C(C=C(O[C@H]3CCOC3)C(OC)=C2)=C(N[C@@H](C2=CC(C(F)(F)F)=CC(N)=C2)C)N=C1C
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BI-3406 Usage And Synthesis
Uses
BI-3406 (compound I-6) is an orally active, highly potent and selective inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1) with an IC50 of 6 nM. BI-3406 potently reduces the formation of GTP-loaded KRAS, and inhibits MAPK pathway signaling. BI-3406 has anticancer activity[1][2].
IC 50
KRAS-SOS1: 6 nM (IC50)
References
[1] Michael Gmachl, et al. Novel benzylamino substituted quinazolines and derivatives as sos1 inhibitors. WO2018115380A1.
[2] Marco H Hofmann, et al. Abstract PL06-01: Discovery of BI-3406: A potent and selective SOS1::KRAS inhibitor opens a new approach for treating KRAS-driven tumors. December 2019.
BI-3406Supplier
ShangHai Caerulum Pharma Discovery Co., Ltd. Gold
- Tel
- 18149758185
- sales-cpd@caerulumpharma.com
Anqing YanZhi Pharma Discovery Co.,Ltd. Gold
- Tel
- 18055651951
- 2272561977@qq.com
Shanghai Topbiochem Technology Co., Ltd
- Tel
- 021-58170097
- info@topbiochem.com
Guangzhou Isun Pharmaceutical Co., Ltd
- Tel
- 020-39119399 18927568969
- isunpharm@qq.com
Nanjing Sunlida Biological Technology Co., Ltd.
- Tel
- 025-57798810
- sales@sunlidabio.com
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