DIDO1 Antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat

Background

The putative transcription factor DIDO1 contains a pair of zinc finger motifs and is upregulated by apoptotic stimuli. DIDO1 is expressed in the developing limb and may play a role in controlling programmed cell death during development. Nuclear translocation of DIDO1 during apoptosis is associated with its apoptotic activity. Alternative splicing produces the DIDO-1, -2 and -3 isoforms, whose targeted disruption in mice produces a phenotype similar to myelodysplastic/myeloproliferative disease in humans. DIDO3, the largest of the splice variants, is associated with the centrosome and plays a role in mitotic checkpoint and chromosome stability.

References

[1] García-Domingo, D. et al. (1999) Proc Natl Acad Sci U S A 96, 7992-7.
[2] Gomes, I. et al. (2002) Blood 100, 107-19.
[3] Fütterer, A. et al. (2005) J Clin Invest 115, 2351-62.
[4] Trachana, V. et al. (2007) Proc Natl Acad Sci U S A 104, 2691-6.

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