PGK1 antibody Usage And Synthesis

Source

Rabbit

Applications

PGK1 antibody has been tested by ELISA, Western blot analysis, ICC/IF and Flow cytometry to assure specificity and reactivity.

Reactivity

Human;Mouse;Rat

Immunogen

Anti-human PGK1 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human PGK1 protein 1-417 amino acids purified from E. coli.

Background

PGK1 is an X-linked enzyme that has a major role in the glycolytic pathway. PGK1 is a glycolytic enzyme which catalyzes the conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate, generating an ATP molecule. PGK1 may also act as a cofactor for polymerase alpha. Defects in the PGK1 gene are usually associated with chronic hemolytic anemia, though it can be accompanied by either mental retardation or muscular disease (rhabdomyolysis). Overexpression of PGK1 and its signalling targets are possibly an expression-pathway in diffuse primary gastric carcinomas promoting peritoneal dissemination. It was shown that PGK1 is differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia.

References

[1] Beutler, E. (2007) Br J Haematol 136, 3-11.
[2] Wilson, R.B. et al. (2019) Pleura Peritoneum 4, 20190003.
[3] Yu, T. et al. (2017) Cancer Res 77, 5782-94.
[4] Hu, H. et al. (2017) Hepatology 65, 515-28.
[5] Cao, H. et al. (2017) Cancer Chemother Pharmacol 79, 985-94.
[6] Li, X. et al. (2016) Mol Cell 61, 705-19.
[7] Qian, X. et al. (2017) Mol Cell 65, 917-931.e6.
[8] Qian, X. et al. (2019) Mol Cell, pii: S1097-2765(19)30622-7. doi: 10.1016/j.molcel.2019.08.006.

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