SYNGR1 antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat

Background

Synaptogyrin, or SYNGR, are a family of tyrosine-phosphorylated proteins, including neuronal SYNGR1 and SYNGR3 that are found in synaptic vesicles and contribute to the proper synapse function. Synaptogyrin-2 expresses ubiquitously and it is not only associated with synaptic vesicles, but also plays an important role in exocytosis processes. In addition, it has been shown that SYNGRs modulate calcium currents in excitable cells during potassium chloride-dependent exocytosis. SYNGR3 and SYNGR1 specifically localize in synaptic vesicles. SYNGR1 modulates synaptic vesicle function similar to SYNGR3. SYNGR1 and SYNGR3 contribute to the neurotransmitter release in neurons by interactions with the GABA and VGLUT transporters in primary neurons and in C. elegans. SYNGRs are associated with disease including Schizophrenia and Alzheimer's disease.

References

[1] Kedra, D. et al. (1998) Hum Genet 103, 131-41.
[2] Janz, R. et al. (1999) Neuron 24, 687-700.
[3] Sugita, S. et al. (1999) J Biol Chem 274, 18893-901.
[4] Belizaire, R. et al. (2004) J Comp Neurol 470, 266-81.
[5] Bragina, L. et al. (2010) Neuroscience 165, 934-43.
[6] Abraham, C. et al. (2011) Neuroscience 190, 75-88.
[7] Verma, R. et al. (2005) J Hum Genet 50, 635-40.
[8] Cheng, M.C. and Chen, C.H. (2007) J Psychiatr Res 41, 1027-31.
[9] Liu, C. et al. (2016) J Biol Chem 291, 8173-88.
[10] McInnes, J. et al. (2018) Neuron 97, 823-835.e8.

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