ATPIF1 antibody Usage And Synthesis

Source

Rabbit

Reactivity

Human;Mouse;Rat;Monkey

Background

The ATPase inhibitor factor 1 gene encodes a mitochondrial ATPase inhibitor that limits ATP depletion when mitochondrial respiration is impaired. ATPIF1 becomes activated following a drop in pH, binding to β-F1-ATPase, thereby inhibiting the hydrolase activity of the H+-ATP synthase. In addition to its role as an ATP hydrolase, ATPIF1 has also been shown to play a regulatory role in cellular energy metabolism by triggering the induction of aerobic glycolysis in cancer cells resulting in their Warburg phenotype. Research studies demonstrate that the overexpression of ATPIF1 in several human carcinomas further supports its participation in oncogenesis and provides insight into the altered metabolism of cancer cells, which includes the reprogramming of energetic metabolism toward glycolysis.

References

[1] Gledhill, J.R. et al. (2007) Proc Natl Acad Sci USA 104, 15671-6.
[2] Cabezón, E. et al. (2003) Nat Struct Biol 10, 744-50.
[3] Sánchez-Cenizo, L. et al. (2010) J Biol Chem 285, 25308-13.
[4] Wallace, D.C. (2005) Cold Spring Harb Symp Quant Biol 70, 363-74.

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