NH-bis(PEG2-Boc)
NH-bis(PEG2-Boc) Basic information
- Product Name:
- NH-bis(PEG2-Boc)
- Synonyms:
-
- NH-bis(PEG2-Boc)
- NH-bis(C2-PEG2-NH-Boc)
- 5,8,14,17-Tetraoxa-2,11,20-triazaheneicosanedioic acid, 1,21-bis(1,1-dimethylethyl) ester
- Di-tert-butyl (3,6,12,15-tetraoxa-9-azaheptadecane-1,17-diyl)dicarbamate
- CAS:
- 2182601-69-8
- MF:
- C22H45N3O8
- MW:
- 479.61
- Mol File:
- 2182601-69-8.mol
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NH-bis(PEG2-Boc) Chemical Properties
- Boiling point:
- 577.0±50.0 °C(Predicted)
- Density
- 1.064±0.06 g/cm3(Predicted)
- storage temp.
- Storage temp. 2-8°C
- solubility
- Soluble in Water, DMSO, DMF, DCM
- pka
- 11.93±0.46(Predicted)
- form
- Liquid
- color
- Colorless to light yellow
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NH-bis(PEG2-Boc) Usage And Synthesis
Description
NH-bis(PEG2-Boc) is a Boc protected amine molecule whiich is reactive with carboxylic acids, activated NHS esters,. Boc can be deprotected under acidic conditions.
Uses
NH-bis(C2-PEG2-NH-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
IC 50
PEGs; Alkyl/ether
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
NH-bis(PEG2-Boc)Supplier
Shanghai YuanYe Biotechnology Co., Ltd.
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Beijing Jin Ming Biotechnology Co., Ltd.
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TargetMol Chemicals Inc.
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