Benzoic acid, 4-[[(cyclopropylmethyl)[4-(2-fluorophenoxy)benzoyl]amino]methyl]-
Benzoic acid, 4-[[(cyclopropylmethyl)[4-(2-fluorophenoxy)benzoyl]amino]methyl]- Basic information
- Product Name:
- Benzoic acid, 4-[[(cyclopropylmethyl)[4-(2-fluorophenoxy)benzoyl]amino]methyl]-
- Synonyms:
-
- Benzoic acid, 4-[[(cyclopropylmethyl)[4-(2-fluorophenoxy)benzoyl]amino]methyl]-
- LPA1,fibrosis,LPL Receptor,Lysophospholipid Receptor,TAK615,modulator,TAK-615,NAM,inhibit,pulmonary,Inhibitor,allosteric,TAK 615,negative
- TAK-615, 10 mM in DMSO
- 4-(((Cyclopropylmethyl)(4-(2-fluorophenoxy)benzoyl)amino)methyl)benzoic acid
- 4-((N-(Cyclopropylmethyl)-4-(2-fluorophenoxy)benzamido)methyl)benzoic acid
- CAS:
- 1664335-55-0
- MF:
- C25H22FNO4
- MW:
- 419.44
- Mol File:
- 1664335-55-0.mol
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Benzoic acid, 4-[[(cyclopropylmethyl)[4-(2-fluorophenoxy)benzoyl]amino]methyl]- Chemical Properties
- Boiling point:
- 607.4±55.0 °C(Predicted)
- Density
- 1.302±0.06 g/cm3(Predicted)
- pka
- 4.22±0.10(Predicted)
- form
- Solid
- color
- White to off-white
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Benzoic acid, 4-[[(cyclopropylmethyl)[4-(2-fluorophenoxy)benzoyl]amino]methyl]- Usage And Synthesis
Uses
TAK-615 is a negative allosteric modulator (NAM) of the LPA1 receptor for the research of pulmonary fibrosis. TAK-615 binds the LPA1 receptor with high affinity (Kd high affinity of 1.7 nM and Kd low affinity of 14.5 nM)[1].
IC 50
LPA1 Receptor: 1.7-14.5 nM (Kd)
References
[1] Jonathan Ellery, et al. Identification of Compounds Acting as Negative Allosteric Modulators of the LPA 1 Receptor. Eur J Pharmacol. 2018 Aug 15;833:8-15. DOI:10.1016/j.ejphar.2018.05.040
Benzoic acid, 4-[[(cyclopropylmethyl)[4-(2-fluorophenoxy)benzoyl]amino]methyl]-Supplier
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