2-ETHOXY-MALONIC ACID DIETHYL ESTER Chemical Properties

Boiling point:

261℃

Density 

1.070

Flash point:

108℃

storage temp. 

Sealed in dry,Room Temperature

pka

13.29±0.46(Predicted)

Appearance

Colorless to light yellow Liquid

2-ETHOXY-MALONIC ACID DIETHYL ESTER Usage And Synthesis

Uses

Diethyl ethoxymalonate is a hydroxyl malonic acid ester and a commonly used reagent in organic synthesis.

Synthesis

Example 1: Scheme 4 Preparation of diethyl 2-ethoxy-malonate A mixture of diethyl oxalate (39.23 ml, 1.12 eq.) and ethyl 2-ethoxyacetate (34.95 ml, 1 eq.) was added dropwise to a slurry of sodium ethanolate (18.64 g, 1.07 eq.) in toluene (100 ml) at 45-50 °C. After the dropwise addition was completed, the reaction mixture was heated to 70-80°C and maintained for 2 hours. After completion of the reaction, the mixture was cooled and poured into 70 ml of 14% hydrochloric acid solution. The resulting mixture was extracted with ethyl acetate (EA), the organic layers were combined and washed with brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 55.86 g (93.7% yield) of the target product diethyl 2-ethoxy-malonate.

References

[1] Patent: WO2011/80568, 2011, A2. Location in patent: Page/Page column 47-48

2-ETHOXY-MALONIC ACID DIETHYL ESTER(37555-99-0)Related Product Information

• TRIPHENYLETHOXYSILANE
• CHLOROMETHYLDIMETHYLETHOXYSILANE
• ETHOXYTRIETHYLSILANE
• Ethoxymethylenemalononitrile
• Ethoxyacetic acid
• Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate
• ETHOXY-IMINO-ACETIC ACID ETHYL ESTER
• BISPHENOL A ETHOXYLATE DIMETHACRYLATE
• Triethyl orthoformate
• Diethyl malonate
• Diethyl ethoxymethylenemalonate
• TARTRONIC ACID
• Ethyl (triphenylphosphoranylidene)acetate
• Ethyl 2-(triphenylphosphoranylidene)propionate
• DIMETHYL METHOXYMALONATE
• 2-ETHOXY-MALONIC ACID DIETHYL ESTER
• ETHYL (S)-(-)-2-METHOXYPROPIONATE
• DIETHYL 2-HYDROXYMALONATE