6-Chlorohexanol Chemical Properties

Melting point:

102 °C

Boiling point:

108-112 °C14 mm Hg(lit.)

Density 

1.024 g/mL at 25 °C(lit.)

vapor pressure 

1.066hPa at 21.1℃

refractive index 

n20/D 1.456(lit.)

Flash point:

210 °F

storage temp. 

Sealed in dry,Room Temperature

solubility 

Soluble in dimethylformamide.

form 

Liquid

pka

15.17±0.10(Predicted)

color 

Clear colorless to pale yellow

Specific Gravity

1.024

Water Solubility 

11.3g/L at 20℃

BRN 

1697307

InChIKey

JNTPTNNCGDAGEJ-UHFFFAOYSA-N

LogP

1.86 at 30℃

CAS DataBase Reference

2009-83-8(CAS DataBase Reference)

NIST Chemistry Reference

1-Hexanol, 6-chloro-(2009-83-8)

EPA Substance Registry System

1-Hexanol, 6-chloro- (2009-83-8)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21-36/38-36/37/38-20/21/22

Safety Statements 

26-36/37-36/37/39

RIDADR 

2810

WGK Germany 

3

RTECS 

MO9160000

TSCA 

T

HazardClass 

IRRITANT

HS Code 

29055900

Toxicity

mouse,LD50,intraperitoneal,> 100mg/kg (100mg/kg),Journal of Organic Chemistry. Vol. 21, Pg. 739, 1956.

MSDS

• Language:English Provider:1-Chloro-6-hydroxyhexane
• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

6-Chlorohexanol Usage And Synthesis

Chemical Properties

clear colorless to pale yellow liquid

Uses

6-Chloro-1-hexanol is used in the preparation of its corresponding bromide by reaction with sodium bromide using N,N-dimethylformamide and dibromomethane (2:1) as a solvent. It is utilized in the selective elimination of 6-chloro-1-hexene from esters of 6-chloro-1-hexanol.

Preparation

6-Chlorohexanol can be prepared by the reaction of 1,6-hexanediol with hydrochloric acid without the use of a catalyst or cuprous chloride. It can also be synthesised by reacting 2,6-dichlorophenol with hydrochloric acid and sodium hydroxide in the presence of azobenzene.

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 3, p. 446, 1955
Tetrahedron Letters, 36, p. 3161, 1995 DOI: 10.1016/0040-4039(95)00501-3

6-Chlorohexanol(2009-83-8)Related Product Information

• Chlorhexidine diacetate
• 2-(2-Chloroethoxy)ethanol
• 1-Naphthyl isocyanate
• CLOPROSTENOL
• 1-Hexanol
• Epichlorohydrin
• 3-Chloro-1,2-propanediol
• Cloprostenol sodium
• Chlorendic anhydride
• METHYL ADIPOYL CHLORIDE
• 6-CHLORO-N-HEXANOIC ACID
• (+)-CAMPHANIC ACID CHLORIDE
• 2,2,6,6-TETRACHLOROCYCLOHEXANOL
• 2-(CHLOROMETHYL)TETRAHYDROPYRAN
• Clindamycin
• 6-CHLORO-6-DEOXY-D-MANNOSE
• Difluorochloromethane
• Diallyl 1,4,5,6,7,7-hexachlorobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylate