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TOS-ARG-OME HCL

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TOS-ARG-OME HCL Basic information

Product Name:
TOS-ARG-OME HCL
Synonyms:
  • N-4-Tosyl-L-arginine methyl ester hydrochloride
  • N-Alpha-p-tosyl-l-arginine methyl ester hydrochloride ,99%
  • Ala-Ala-Ala-OMe
  • L-Ala-L-Ala-L-Ala-OMe
  • Nα-Tosyl-L-arginine methyl·hydrochloric acid
  • Nalpha-4-Tosyl-L-arginine methyl ester hydrochloride,99%
  • N-a-Tosyl-L-Arginine methyl ester hydrochloride
  • Tos-Arg-Ome x HCl ,≥99%
CAS:
1784-03-8
MF:
C14H23ClN4O4S
MW:
378.87
EINECS:
217-235-1
Product Categories:
  • Amino Acids
  • Arginine [Arg, R]
  • Amino Acids and Derivatives
  • Amino hydrochloride
Mol File:
1784-03-8.mol
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TOS-ARG-OME HCL Chemical Properties

Melting point:
145-147(lit.)
alpha 
-14 º (c=4, H2O)
refractive index 
-14 ° (C=4, H2O)
storage temp. 
-20°C
solubility 
methanol: 50 mg/mL, clear, colorless
form 
Fine Crystalline Powder
color 
White
BRN 
3922357
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
InChIKey
JIQFFACVQXXHMY-YDALLXLXSA-N
CAS DataBase Reference
1784-03-8(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
22-24/25-37/39-26
WGK Germany 
3
3-10
HS Code 
29252900

MSDS

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TOS-ARG-OME HCL Usage And Synthesis

Description

TAME (1784-03-8) binds to the ubiquitin ligase anaphase-promoting complex (APC) preventing its activation by Cdc20 and Cdh1 and resulting in mitotic arrest.1,2

Chemical Properties

white fine crystalline powder

Uses

enzyme inhibitor

Uses

Substrate for trypsin, thrombin, plasmin and other proteases.

Uses

N-4-Tosyl-L-arginine Methyl Ester Hydrochloride acts as a synthetic substrate of serine proteases and thus is used to determine serine proteases from diverse organic sources.

Biochem/physiol Actions

Nα-p-Tosyl-L-arginine methyl ester (TAME) binds to anaphase-promoting complex (APC) and prevents its activation by Cdc20 and Cdh1.

References

1) Zeng et al. (2010) Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage; Cancer Cell, 18 382 2) Zeng and King (2012) An APC/C inhibitor stabilizes Cyclin B1 by prematurely terminating ubiquitination; Nat. Chem. Biol., 8 383

TOS-ARG-OME HCLSupplier

J & K SCIENTIFIC LTD.
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