TOS-ARG-OME HCL Chemical Properties

Melting point:

145-147(lit.)

alpha 

-14 º (c=4, H2O)

refractive index 

-14 ° (C=4, H2O)

storage temp. 

-20°C

solubility 

methanol: 50 mg/mL, clear, colorless

form 

Fine Crystalline Powder

color 

White

BRN 

3922357

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.

InChIKey

JIQFFACVQXXHMY-YDALLXLXSA-N

CAS DataBase Reference

1784-03-8(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

22-24/25-37/39-26

WGK Germany 

3

F 

3-10

HS Code 

29252900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

TOS-ARG-OME HCL Usage And Synthesis

Description

TAME (1784-03-8) binds to the ubiquitin ligase anaphase-promoting complex (APC) preventing its activation by Cdc20 and Cdh1 and resulting in mitotic arrest.1,2

Chemical Properties

white fine crystalline powder

Uses

enzyme inhibitor

Uses

Substrate for trypsin, thrombin, plasmin and other proteases.

Uses

N-4-Tosyl-L-arginine Methyl Ester Hydrochloride acts as a synthetic substrate of serine proteases and thus is used to determine serine proteases from diverse organic sources.

Biochem/physiol Actions

Nα-p-Tosyl-L-arginine methyl ester (TAME) binds to anaphase-promoting complex (APC) and prevents its activation by Cdc20 and Cdh1.

References

1) Zeng et al. (2010) Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage; Cancer Cell, 18 382 2) Zeng and King (2012) An APC/C inhibitor stabilizes Cyclin B1 by prematurely terminating ubiquitination; Nat. Chem. Biol., 8 383

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