4,5,6,7-TETRAHYDROINDOLE Chemical Properties

Melting point:

53-57 °C(lit.)

Boiling point:

64 °C(Press: 0.1 Torr)

Density 

1.057±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

pka

18.03±0.20(Predicted)

BRN 

108853

InChIKey

KQBVVLOYXDVATK-UHFFFAOYSA-N

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39

WGK Germany 

3

F 

1-10

HS Code 

2933998090

MSDS

• Language:English Provider:SigmaAldrich

4,5,6,7-TETRAHYDROINDOLE Usage And Synthesis

Uses

4,5,6,7-Tetrahydro-1H-indole is used in preparation of chiral tetraaryl-substituted Methane. Also, used in preparation of 4-substituted Phenylamidine derivatives used for controlling phytopathogenic microorganisms.

Uses

4,5,6,7-Tetrahydroindole was used as reactant in:

• synthesis of ethyl 3-(4,5,6,7-tetrahydroindol-2-yl)-2-propynoate
• preparation of BODIPY dyes
• N-alkylation with chloromethyloxirane
• preparation of hydroindolepropynoate by chemo- and regioselective solvent-free ethynylation
• palladium- and copper-free cross-coupling of halopropynoates
• preparation of carbonylalkenyl indoles via coupling with dicarbonyl compounds
• 1:2 annelation of 4,5,6,7-tetrahydroindole with 1-benzoyl-2-phenylacetylene

General Description

4,5,6,7-Tetrahydroindoles, due to their easy aromatization, are good intermediates to synthesize indoles. 4,5,6,7-Tetrahydroindole on condensation with cyanoacetate leads to 1-ethylthio-2-cyano-4,5,6,7-tetrahydrocyclohexa-[c]-3H-pyrrolizin-3-one.

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