NICLOFOLAN Chemical Properties

Boiling point:

251.5°C (rough estimate)

Density 

1.8594 (rough estimate)

refractive index 

1.7350 (estimate)

pka

4.34±0.40(Predicted)

EPA Substance Registry System

Niclofolan (10331-57-4)

Safety Information

Toxicity

bird - wild,LD50,oral,13mg/kg (13mg/kg),Toxicology and Applied Pharmacology. Vol. 21, Pg. 315, 1972.

NICLOFOLAN Usage And Synthesis

Chemical Properties

Orange-yellow crystalline powder. Melting point 178-182 ℃. Soluble in acetone, glacial acetic acid and sodium hydroxide solution, slightly soluble in water and ethanol.

Uses

Niclofolan can be used as deworming drug and anti-creep drug. It is used for prevention and treatment of hepatic chioniasis of cattle and sheep.

Definition

ChEBI: Niclofolan is a polychlorobiphenyl.

Synthesis

Niclofolan is obtained by nitration of 5,5 '-dichloro-2, 2' dihydroxybiphenyl. The nitration was carried out in acetic acid at a temperature not exceeding 20℃. Then activated carbon was added for reflux decolorization for 1h. The filter was pumped with a nitrate filter rod. The filtrate was cooled below 15℃ and crystallized. Dinitrochlorophenol was obtained by filtration, washing with acetic acid and drying. The yield is 60%.

NICLOFOLAN(10331-57-4)Related Product Information

• Ferric nitrate nonahydrate
• Erbium(III) nitrate pentahydrate
• Cobaltous nitrate hexahydrate
• Nitrazine Yellow
• Ceric ammonium nitrate
• Isosorbide dinitrate
• Sodium nitroprusside dihydrate
• Lanthanum(III) nitrate hexahydrate
• THORIUM NITRATE HYDRATE
• ZIRCONIUM DINITRATE OXIDE
• Nitroclofene
• CERIUM(III) NITRATE HEXAHYDRATE
• Ferric nitrate
• LANTHANUM NITRATE
• Lithium nitrate
• MERCUROUS NITRATE
• NICLOFOLAN
• 5-chloro[1,1'-biphenyl]-2-ol