3-Amino-4-methylphenol
3-Amino-4-methylphenol Basic information
- Product Name:
- 3-Amino-4-methylphenol
- Synonyms:
-
- 3-amino-p-cresol
- 3-AMINO-4-METHYLPHENOL
- 5-Hydroxy-o-toluidine
- 2-AMINO-4-HYDROXYTOLUENE
- 5-Hydroxy-2-methylaniline
- m-Amino-p-cresol
- 2-aMino-4-hydroxytoluene, 98%+
- 3-Amino-4-Methylphenol 98%
- CAS:
- 2836-00-2
- MF:
- C7H9NO
- MW:
- 123.15
- EINECS:
- 220-622-8
- Product Categories:
-
- pharmacetical
- Phenol&Thiophenol&Mercaptan
- Mol File:
- 2836-00-2.mol
3-Amino-4-methylphenol Chemical Properties
- Melting point:
- 156-157°C
- Boiling point:
- 229.26°C (rough estimate)
- Density
- 1.0877 (rough estimate)
- refractive index
- 1.5706 (estimate)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder to crystal
- pka
- 10.32±0.18(Predicted)
- color
- Light yellow to Brown to Dark green
- CAS DataBase Reference
- 2836-00-2(CAS DataBase Reference)
- EPA Substance Registry System
- 3-Amino-4-methylphenol (2836-00-2)
Safety Information
- Hazard Codes
- Xi
- Hazard Note
- Irritant
- HS Code
- 2922290090
MSDS
- Language:English Provider:5-Hydroxy-o-toluidine
3-Amino-4-methylphenol Usage And Synthesis
General Description
Crystals.
Air & Water Reactions
3-Amino-4-methylphenol may be sensitive to prolonged exposure to air.
Reactivity Profile
3-Amino-4-methylphenol reacts with strong oxidizing agents.
Fire Hazard
Flash point data for 3-Amino-4-methylphenol are not available. 3-Amino-4-methylphenol is probably combustible.
Synthesis
2042-14-0
2836-00-2
The general procedure for the synthesis of 3-amino-4-methylphenol from 4-methyl-3-nitrophenol was as follows: 4-methyl-3-nitrophenol (77 mg, 0.50 mmol), Fe nanoparticles (6 mg), and NaBH4 (29 mg, 0.75 mmol) were placed in 1.0 mL of 2 wt. % TPGS/H2O solution, and the reaction was carried out for 2 h at room temperature. Upon completion of the reaction, 56 mg (91% yield) of 3-amino-4-methylphenol was obtained as a white solid (hexane/ethyl acetate = 50:50). The melting point of the product was 154°C-156°C. It was analyzed by GC-MS with m/z of 123 [M], and the spectral data were consistent with those reported in the literature.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2011, vol. 21, # 1, p. 240 - 244
[2] Green Chemistry, 2017, vol. 19, # 3, p. 809 - 815
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 5, p. 1964 - 1978
[4] ACS Catalysis, 2017, vol. 7, # 4, p. 2412 - 2418
[5] Patent: WO2018/208132, 2018, A1. Location in patent: Paragraph 704-708
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