5,7-DIHYDROXY-3-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE Chemical Properties

Melting point:

234 °C

Boiling point:

552.0±50.0 °C(Predicted)

Density 

1.46±0.1 g/cm3(Predicted)

solubility 

DMF: 20 mg/ml
DMSO: 15 mg/ml

pka

6.32±0.40(Predicted)

LogP

2.400 (est)

5,7-DIHYDROXY-3-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE Usage And Synthesis

Uses

Ermanin is a useful research chemical used in HIV-1 integrase inhibition. Ermanin exhibits actioxidant properties against peroxyl and hydroxyl radicals.

Definition

ChEBI: 3,4'-dimethylkaempferol is a dimethoxyflavone that is kaempferol in which the hydroxy groups at position 3 and 4' have been replaced by methoxy groups. It is a component of bee glue and isolated from several plant species including Tanacetum microphyllum. It has a role as an anti-inflammatory agent, an antimycobacterial drug, an apoptosis inducer, an antineoplastic agent and a plant metabolite. It is a dihydroxyflavone and a dimethoxyflavone. It is functionally related to a kaempferol.

IC 50

iNOS; Bacterial; COX-2

References

[1] QIONG DING . The critical role of glutathione redox homeostasis towards oxidation in ermanin-induced melanogenesis[J]. Free Radical Biology and Medicine, 2021, 176: Pages 392-405. DOI: 10.1016/j.freeradbiomed.2021.09.017
[2] JOSÉ ANTONIO GUERRA. Inhibition of inducible nitric oxide synthase and cyclooxygenase-2 expression by flavonoids isolated from Tanacetum microphyllum[J]. International immunopharmacology, 2006, 6 11: Pages 1723-1728. DOI: 10.1016/j.intimp.2006.08.012
[3] NADINE DE MEYER. 4’-Hydroxy-3-methoxyflavones with potent antipicornavirus activity[J]. Journal of Medicinal Chemistry, 1991, 34 2: 736-746. DOI: 10.1021/jm00106a039

5,7-DIHYDROXY-3-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE(20869-95-8)Related Product Information

• AYANIN
• ARTEMETIN
• QUERCETIN-3,5,7,3',4'-PENTAMETHYL ETHER
• 3,7,3',4'-TETRAMETHYLGOSSYPETIN
• CASTICIN
• 3,4'-DIMETHOXY-3',5,7-TRIHYDROXYFLAVONE
• QUERCETIN-3,7,3',4'-TETRAMETHYL ETHER
• Icariin
• KAEMPFEROL-3,7,4'-TRIMETHYL ETHER
• Ombuoside
• 2'-O-RHAMNOSYLICARISIDE II
• Venalot
• 5,7-DIHYDROXY-3-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE
• 3'-BENZYLOXY-5,7-DIHYDROXY-3,4'-DIMETHOXYFLAVONE
• 3,3',4',5,6,7,8-heptamethoxyflavone
• QUERCETINPENTAACETATE
• 3,5-DIHYDROXY-7-METHOXY-2-(4-METHOXY-PHENYL)-CHROMEN-4-ONE
• 3-[[6-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one, tris(2-hydroxyethyl) ether