Enoximone Chemical Properties

Melting point:

255-258°C

Density 

1.33

storage temp. 

Sealed in dry,Room Temperature

solubility 

DMSO: 28 mg/mL, soluble

pka

10.37±0.70(Predicted)

form 

solid

color 

light yellow

CAS DataBase Reference

77671-31-9(CAS DataBase Reference)

Safety Information

RIDADR 

3249

WGK Germany 

3

HazardClass 

6.1(b)

PackingGroup 

III

MSDS

• Language:English Provider:Enoximone
• Language:English Provider:SigmaAldrich

Enoximone Usage And Synthesis

Description

Enoximone is a phosphodiesterase inhibitor indicated for selective use as a cardiostimulant in heart transplant patient maintenance. It is currently being investigated for other indications including acute congestive heart failure.

Originator

Merrell Dow (USA)

Uses

Enoximone is a phosphodiesterase inhibitor used in the treatment of congestive heart failure and is selective to phosphodiesterase 3. Potent PDE-3 inhibitor.

Definition

ChEBI: Enoximone is an aromatic ketone.

brand name

Perfan IV

Biological Activity

Inhibitor of type III phosphodiesterase (PDE3). Increases intracellular cyclic AMP (cAMP) concentrations and enhances myocardial contractility. Also induces concentration-dependent vasodilation in vitro .

Biochem/physiol Actions

Selective phosphodiesterase III (PDE3) inhibitor. Prevents the degradation of cAMP by PDE. Increased cAMP results in enhanced contractility of the heart.

storage

Store at +4°C

Enoximone(77671-31-9)Related Product Information

• Methyl salicylate
• Imidazole
• Hexamethylphosphoramide
• Dihydromyrcenol
• 1-Methylimidazole
• Basic Violet 1
• Phenylmethylsulfonyl fluoride
• Tribenuron methyl
• Methylparaben
• Methyl acrylate
• Methanol
• Kresoxim-methyl
• 1-(2,6-Dimethylphenoxy)-2-propanamine
• Methyl
• 4-Ethyl-1,3-dihydro-imidazol-2-one
• 4,5-DIMETHYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONE
• 4-ACETYL-5-METHYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONE
• enoximone sulfoxide