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ETH 1001

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ETH 1001 Basic information

Product Name:
ETH 1001
Synonyms:
  • (-)-(R,R)-N,N'-BIS[11-(ETHOXYCARBONYL)UNDECYL]-N,N',4,5-TETRAMETHYL-3,5-DIOXAOCTANEDIAMIDE
  • (-)-(R,R)-N,N'-BIS-[11-(ETHOXYCARBONYL)UNDECYL]-N,N'-4,5-TETRAMETHYL-3,6-DIOXAOCTANEDIAMIDE
  • CA 1001
  • CALCIUM IONOPHORE I
  • CALCIUM IONOPHORE
  • ETH 1001
  • DIETHYL-N,N'-[(4R,5R)-4,5-DIMETHYL-1,8-DIOXO-3,6-DIOXAOCTAMETHYLENE]BIS(12-METHYLAMINODODECANOATE)
  • diethyl [R-(R*,R*)]-13,17,18,22-tetramethyl-14,21-dioxo-16,19-dioxa-13,22-diazatetratriacontanedioate
CAS:
58801-34-6
MF:
C38H72N2O8
MW:
684.99
EINECS:
261-449-8
Mol File:
58801-34-6.mol
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ETH 1001 Chemical Properties

Boiling point:
715.1±50.0 °C(Predicted)
Density 
1.000±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Soluble in DMSO
form 
Light yellow, translucent, highly viscous oil
pka
-0.52±0.70(Predicted)
color 
Colorless to light yellow
BRN 
2343275
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Safety Information

WGK Germany 
3
F 
9-23

MSDS

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ETH 1001 Usage And Synthesis

Description

Calcium ionophore I is a Ca2+-selective ionophore for biological membranes that can be used in microelectrodes for the determination of intracellular Ca2+-activities and of slowly changing Ca2+ levels.

Purification Methods

This is a neutral Ca selectophore. It can be purified by thick layer (2mm) chromatography (Kieselgel F245) and eluted with Me2CO/CHCl3 (2:1). [Ammann et al. Helv Chim Acta 56 1780 1973, Simon & Carafoli Methods Enzymol 56 439 1977.]

References

dagostino m, lee co. neutral carrier na+- and ca2+-selective microelectrodes for intracellular application. biophys j. 1982 dec;40(3):199-207.caroni p, gazzotti p, vuilleumier p, et al. ca2+ transport mediated by a synthetic neutral ca2+ -ionophore in biological membranes. biochim biophys acta. 1977 nov 1;470(3):437-45.hinds tr, vincenzi ff. the effect of eth 1001 on ion fluxes across red blood cell membranes. cell calcium. 1985 jun;6(3):265-79.lücke a, lehmenkühler a, speckmann ej. the influence of the convulsant pentylenetetrazol on ca2+-selective microelectrodes (neutral carrier eth 1001). j neurosci methods. 1989 aug;29(2):139-42.lee mh, yoo cl, lee js, et al. tweezer-type neutral carrier-based calcium-selective membrane electrode with drastically reduced anionic interference. anal chem. 2002 jun 1;74(11):2603-7.

ETH 1001Supplier

J & K SCIENTIFIC LTD.
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Tianjin heowns Biochemical Technology Co., Ltd.
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Sinopharm Chemical Reagent Co,Ltd.
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86-21-63210123
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Shanghai Rechem science Co., Ltd.
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Shanghai Chaolan Chemical Technology Center
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021-QQ：65489617 15618227136
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