KDDIA-PC Chemical Properties

storage temp. 

Store at -20°C

solubility 

DMF: .5 mg/ml; DMSO: .5 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): 5 mg/ml

KDDIA-PC Usage And Synthesis

Description

Oxidized low-density lipoprotein (oxLDL) particles contain low molecular weight species which are cytotoxic and pro-atherogenic. Many of these substances were recently isolated and purified from oxLDL, and identified as phosphatidylcholine species containing a fragmented, oxidized short-chain fatty acid remnant at the sn-2 position. KDdiA-PC is one of the most potent CD36 ligands among the oxLDL species. KDdiA-PC confers CD-36 scavenger receptor binding affinity to LDL at a frequency of only two to three KDdiA-PC molecules/LDL particle, and may be one of the more important structural determinants of oxLDL.

Uses

KDdiA-PC is one of the most potent CD36 ligands in oxidized LDL (oxLDL)[1].

Definition

ChEBI: PKDdiA-PC is a 1,2-diacyl-sn-glycero-3-phosphocholine.

References

[1] Sara Els?e, et al. Apolipoprotein M binds oxidized phospholipids and increases the antioxidant effect of HDL. Atherosclerosis. 2012 Mar;221(1):91-7. DOI:10.1016/j.atherosclerosis.2011.11.031