Tioxolone Chemical Properties

Melting point:

158-160 °C(lit.)

Boiling point:

267.1°C (rough estimate)

Density 

1.4844 (rough estimate)

refractive index 

1.5151 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

95% ethanol: soluble50mg/mL, clear to very slightly hazy, colorless to yellow

form 

A solid

pka

8.14±0.20(Predicted)

color 

Light yellow to yellow

Merck 

9456

LogP

1.770 (est)

CAS DataBase Reference

4991-65-5(CAS DataBase Reference)

NIST Chemistry Reference

Tioxolone(4991-65-5)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

22-36/37/38

Safety Statements 

26

WGK Germany 

3

RTECS 

DM2953750

HS Code 

2934999090

MSDS

• Language:English Provider:Tioxolone
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

Tioxolone Usage And Synthesis

Chemical Properties

light yellow to beige powder

Originator

Acnosan,Unia

Uses

6-Hydroxy-1,3-benzoxathiol-2-one was used in the synthesis of heterocycle-phosphor esters having potential antimicrobial activity.

Uses

antiseborrhoic

Definition

ChEBI: A 1,3-benzoxathiole having a hydroxy substituent at the 6-position.

Manufacturing Process

40 g potassium thiocyanate in 50 ml of water are added, while stirring at room temperature, to a solution of 11 g of resorcinol and 50 g of crystallized copper sulfate in 250 ml of water. The black cupric thiocyanate formed becomes colorless after a short time, which indicates that the introduction of thiocyanogen is terminated. The cuprous thiocyanate is removed by filtering with suction and then washed with water; the filtrate is mixed with 50 ml of a 2 N sodium carbonate solution, whereby the imino-thiocarbonate of resorcinol separates in the form of a colorless crystalline body. The yield amounts to 16 g. The new compound which melts at 149°C dissolves very easily in many organic solvents and in mineral acids.
A 10% solution of the imino-thiocarbonate of resorcinol in 10% hydrochloric acid is heated for 15 min on the steam bath. The 6-hydroxy-1,3-benzoxathiol- 2-one (thiocarbonate free from) nitrogen separates, on cooling, in the form of fine crystals melting at 158°C.

Therapeutic Function

Antiseborreic, Antifungal, Keratolytic

General Description

Antimicrobial and cytostatic properties of 6-hydroxy-1,3-benzoxathiol-2-one has been investigated. Supramolecular structure of 6-hydroxy-1,3-benzoxathiol-2-one has been studied.

Tioxolone(4991-65-5)Related Product Information

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