PILSICAINIDE Chemical Properties

storage temp. 

Sealed in dry,2-8°C

Safety Information

Hazard Codes 

Xn

Risk Statements 

22

PILSICAINIDE Usage And Synthesis

Chemical Properties

Pilsicainide: C17H24N2O?HCl?1/2H20. [88069-49-2]. It is obtained from the crystallization of ethanol-diethyl ether. Odorless, bitter taste, melting point 212 ~ 214℃. It is highly soluble in glacial acetic acid and soluble in methanol, ethanol or water.

Uses

Pilsicainide is a class IC antiarrhythmic drug, suitable for the treatment of patients with ventricular tachycardia ineffective or intolerable to other antiarrhythmic drugs.

Definition

ChEBI: Pilsicainide is a secondary carboxamide resulting from the formal condensation of the amino group of 2,6-dimethylaniline with the carboxy group of (tetrahydro-1H-pyrrolizin-7a(5H)-yl)acetic acid. It is a sodium channel blocker which is used as an antiarrhythmic drug for the management of atrial tachyarrhythmias in Japan. It has a role as an anti-arrhythmia drug and a sodium channel blocker. It is a secondary carboxamide and an organic heterobicyclic compound.

Synthesis

Pilsicainide was obtained from tetrahydrodithickened pyrrole ethyl acetate and 2, 6-dimethylaniline heated and condensed in dioxane at 100℃ under the action of sodium hydride. It is also possible to hydrolyze tetrahydrodithickened pyrrole ethyl acetate and chlorinate it to tetrahydrodithickened pyrrole acetyl chloride, which is then condensed with 2, 6-dimethylaniline.

PILSICAINIDE(88069-67-4)Related Product Information

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• Pilsicainide hydrochoride,Pilsicainide Hydrochloride and intermediates,PILSICAINIDE,PILSICAINIDE HYDROCHLORIDE,PILSICAINIDE HYDROCHLORIDE HEMIHYDRATE
• Pilsicainide HCL