ChemicalBook > Product Catalog > Chemical Reagents > Organic reagents > fatty acid > Difluoroacetic acid
Difluoroacetic acid
Difluoroacetic acid Basic information
- Product Name:
- Difluoroacetic acid
- Synonyms:
-
- 2,2-DIFLUOROACETIC ACID
- 1,1-DIFLUOROACETIC ACID
- VITAS-BB TBB000649
- DIFLUOROACETIC ACID
- Acetic acid, difluoro-
- difluoro-aceticaci
- DIFLUOROACETATE
- Difluoroaceticacid98%
- CAS:
- 381-73-7
- MF:
- C2H2F2O2
- MW:
- 96.03
- EINECS:
- 206-839-0
- Product Categories:
-
- Pharmaceutical Intermediates
- Small molecule
- Organic Fluorides
- Fluorinated Building Blocks
- Fluorinating Reagents & Building Blocks for Fluorinated Biochemical Compounds
- Synthetic Organic Chemistry
- Chemical Synthesis
- Organic Acids
- Synthetic Reagents
- Mol File:
- 381-73-7.mol
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Difluoroacetic acid Chemical Properties
- Melting point:
- -1 °C (lit.)
- Boiling point:
- 132-134 °C (lit.)
- Density
- 1.526 g/mL at 25 °C (lit.)
- vapor pressure
- 11.7hPa at 25℃
- refractive index
- n20/D 1.344(lit.)
- Flash point:
- 174 °F
- storage temp.
- 2-8°C
- solubility
- 540.54g/L in organic solvents at 20 ℃
- form
- Liquid
- pka
- pK1:1.33 (25°C)
- color
- Clear colorless to light brown
- Specific Gravity
- 1.527 (20℃)
- Water Solubility
- 1000g/L at 37℃
- BRN
- 1098588
- InChIKey
- PBWZKZYHONABLN-UHFFFAOYSA-N
- LogP
- 0.601 at 37℃
- CAS DataBase Reference
- 381-73-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Difluoroacetic acid(381-73-7)
- EPA Substance Registry System
- Acetic acid, difluoro- (381-73-7)
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Safety Information
- Hazard Codes
- C
- Risk Statements
- 34-35
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 3265 8/PG 2
- WGK Germany
- 3
- RTECS
- AG9900000
- Hazard Note
- Corrosive
- TSCA
- T
- HazardClass
- 8
- PackingGroup
- II
- HS Code
- 29159080
MSDS
- Language:English Provider:Difluoroacetic acid
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
- Language:English Provider:ALFA
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Difluoroacetic acid Usage And Synthesis
Chemical Properties
clear colorless to light brown liquid
Uses
Used in the preparation of 2-difluoromethylbenzimidazoles, -oxazoles and -thiazoles from ortho-substituted anilines mediated by triphenylphoshine.
Definition
ChEBI: A monocarboxylic acid that is acetic acid in which two of the methyl hydrogens are substituted by fluorines.
Flammability and Explosibility
Non flammable
Purification Methods
Purify the acid by distilling over P2O5. The acid chloride is a fuming liquid b 25o/atm, and the amide has b 108.6o/35mm, m 52o (from *C6H6), and the anilide has b 90o/1mm, 114o/5mm, m 58o [Henne & Pelley J Am Chem Soc 74 1426 1952, Coffman et al. J Org Chem 14 749 1949, NMR: Meyer et al. J Am Chem Soc 75 4567 1953, pK: Wegscheider Z Phys Chem 69 614 1909]. [Beilstein 2 IV 455.]
Difluoroacetic acidSupplier
Shandong Carbon Spring New Materials Co., Ltd. Gold
- Tel
- 13658618215
- 308410472@qq.com
BTC Pharmaceutical CO. Ltd Gold
- Tel
- 0513-0513-68015397 18862996710
- sales12@btcpharm.com
SHANG FLUORO Gold
- Tel
- 021-65170832 15601903708
- qinba_1@163.com
Qingdao Dexin Chemical Co. LTD Gold
- Tel
- 18560810705
- 354907727@qq.com
West fluorine technology co., ltd Gold
- Tel
- 0531-85906692; 15588812394
- 325912682@qq.com
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Difluoroacetic acid(381-73-7)Related Product Information
- Ethyl 2-(Chlorosulfonyl)acetate
- 2-Bromo-2,2-difluoroacetic acid ethyl ester
- Glycine
- Folic acid
- Trifluoroacetic acid
- Trifluoroacetic anhydride
- DIFLUOROACETIC ACID ETHYL ESTER,ETHYL DIFLUOROACETIC ACID
- Fluroxypyr
- DIFLUOROACETIC ACID METHYL ESTER,α,2-Difluoroacetic acid methyl ester
- Ethyl trifluoroacetate
- Citric acid
- Chlorodifluoroacetic acid ethyl ester
- Sodium chlorodifluoroacetate
- Diethyl 2,2-difluoromalonate
- Ascoric Acid
- DIFLUOROACETIC ACID ANHYDRIDE
- TRIMETHYLSILYL TRIFLUOROACETATE
- THALLIUM(III) TRIFLUOROACETATE