HARRINGTONINE
HARRINGTONINE Basic information
- Product Name:
- HARRINGTONINE
- Synonyms:
-
- (3(r))-ter
- 4-methyl-cephalotaxin2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate(es
- alkaloidcfromcephalotaxus
- cephalotaxine,4-methyl(2r)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioat
- nsc124147
- HARRINGTONIN
- HARRINGTONINE
- HT
- CAS:
- 26833-85-2
- MF:
- C28H37NO9
- MW:
- 531.6
- Product Categories:
-
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Alkaloids
- Mol File:
- 26833-85-2.mol
HARRINGTONINE Chemical Properties
- Melting point:
- 73～75℃
- Boiling point:
- 679.4±55.0 °C(Predicted)
- Density
- 1.35±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 25 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
- form
- A crystalline solid
- pka
- 11.62±0.29(Predicted)
- color
- White to light yellow
HARRINGTONINE Usage And Synthesis
Description
The full structure of harringtonine has now been established from a study of the hydrolysis products of this base.
Description
Harringtonine is a natural alkaloid that inhibits protein synthesis at low micromolar concentrations. It immobilizes ribosomes immediately after the initiation of translation. While harringtonine has drawn some interest in mitigating cancer, its homolog homoharrington is more effective, particularly for chronic myelogenous leukemia. The ability of harringtonine to immobilize initiating ribosomes can be used to capture ribosome-
Chemical Properties
White Solid
Uses
A natural product with significant antitumor activities.
Uses
specific anti-leukemia drug
Definition
ChEBI: Harringtonine is an alkaloid.
References
Mikolajczak, Powell, Smith, Tetrahedron, 28, 1995 (1972)
Kelly, McKenna, Christenson, Tetrahedron Lett., 35m (1973)
HARRINGTONINESupplier
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- 010-82848833 400-666-7788
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HARRINGTONINE(26833-85-2)Related Product Information
- PHENTERMINE
- N-Methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine
- LACTIC ACID ISOAMYL ESTER
- Dimethyl malate
- AMYL-2-METHYLBUTYRATE
- HARRINGTONINE
- FEMA 3505
- propyl 2-methylpentanoate
- 1-(3,4-Methylenedioxyphenyl)-2-butanamine
- (R)-(-)-1-OCTEN-3-OL, 99
- HT-2,Toxin HT 2,Mycotoxin HT 2
- arquad2h
- unistoncr-ht20
- Araldite HT 907
- Araldite HT 901,Ht 901
- b-ht92
- Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, hydrolysis products with silica
- HARRINGTONINE(P)