Basic information Uses Safety Supplier Related
ChemicalBook >  Product Catalog >  Chemical Reagents >  Organic reagents >  Aromatic acids >  4-Acetylbenzoic acid

4-Acetylbenzoic acid

Basic information Uses Safety Supplier Related

4-Acetylbenzoic acid Basic information

Product Name:
4-Acetylbenzoic acid
Synonyms:
  • Benzoic acid, 4-acetyl-
  • 4-Acetylbenzoic acid;Aectophenone-4-carboxylic acid
  • Aectophenone-4-carboxylic acid
  • 4-Acetylbenzoic acid, 98+%
  • 4-(1-Oxoethyl)benzoic acid
  • p-Carboxyacetophenone
  • 4-acetylbenzonic acid
  • 4-Acetylbenzoci acid
CAS:
586-89-0
MF:
C9H8O3
MW:
164.16
EINECS:
209-588-5
Product Categories:
  • intermediate
  • Benzoic Acids (Building Blocks for Liquid Crystals)
  • Aromatic Acetophenones & Derivatives (substituted)
  • Bifunctional Compounds (Building Blocks for Liquid Crystals)
  • Building Blocks for Liquid Crystals
  • Functional Materials
  • Drug Intermediates
  • Benzoic acid
Mol File:
586-89-0.mol
More
Less

4-Acetylbenzoic acid Chemical Properties

Melting point:
208-210 °C(lit.)
Boiling point:
251.61°C (rough estimate)
Density 
1.2132 (rough estimate)
refractive index 
1.5380 (estimate)
storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO (Slightly), Methanol (Slightly)
pka
pK1: 3.70 (25°C)
form 
Crystals or Crystalline Powder
color 
White
Water Solubility 
soluble
BRN 
2207355
InChIKey
QBHDSQZASIBAAI-UHFFFAOYSA-N
CAS DataBase Reference
586-89-0(CAS DataBase Reference)
NIST Chemistry Reference
4-Acetylbenzoic acid(586-89-0)
More
Less

Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38-37/38-36
Safety Statements 
37/39-26-36-24/25
WGK Germany 
3
HS Code 
29183000

MSDS

More
Less

4-Acetylbenzoic acid Usage And Synthesis

Uses

4-Acetylbenzoic Acid is an intermediate used to prepare Curcumin Analogs with anti-oxidant activities. It is also used in the synthesis of quinuclidine benzamides as agonists of α7 nicotinic acetylcholine receptors.

Chemical Properties

White to light yellow crystal powder

Uses

4-Acetylbenzoic acid was used in the preparation of an ester-derivative of paclitaxel.

Synthesis Reference(s)

Synthesis, p. 715, 1974 DOI: 10.1055/s-1974-23412

Purification Methods

4-AcDissolve the acid in 5% aqueous NaOH, extract it with Et2O, and acidify the aqueous solution. Collect the precipitate, and recrystallise it from boiling H2O (100 parts) using decolorising charcoal [Pearson et al. J Org Chem 24 504 1959, Pearson et al. J Chem Soc 265 1957, Detweiler & Amstutz J Am Chem Soc 72 2882 1950, Bordwell & Cooper J Am Chem Soc 74 1058 1952]. [Beilstein 10 IV 2769.]

4-Acetylbenzoic acid Preparation Products And Raw materials

Raw materials

4-Acetylbenzoic acidSupplier

BeiJing Hwrk Chemicals Limted Gold
Tel
0757-86329057 18934348241
Email
sales4.gd@hwrkchemical.com
Shanghai Yuqing Chemical Co., Ltd. Gold
Tel
+86-13816254020 +86-18601759286
Email
penny.xu@tianqing-chem.com
Shanghai Hao Yun Chemical Science Co.,Ltd. Gold
Tel
021-68367562 15002147577;
Email
sales@haoyunchem.com
Originchem Co., Ltd Gold
Tel
0523-0523-86200346 15996028822
Email
1583458435@qq.com
Tianjin Zhongxin Chemtech Co., Ltd.
Tel
022-66880623
Email
sales@tjzxchem.com