N-Hydroxyurethane Chemical Properties

Boiling point:

113-116 °C3 mm Hg(lit.)

Density 

1.3895 (rough estimate)

refractive index 

n20/D 1.445(lit.)

Flash point:

>230 °F

storage temp. 

-20°C

solubility 

Diethyl Ether, Dimethyl Sulfoxide, Water

form 

Oil

pka

9.30±0.23(Predicted)

color 

Yellow

BRN 

1747529

CAS DataBase Reference

589-41-3(CAS DataBase Reference)

NIST Chemistry Reference

Carbamic acid, hydroxy-, ethyl ester(589-41-3)

Safety Information

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39

WGK Germany 

2

RTECS 

FB1750000

HS Code 

2928009090

Toxicity

LD50 intraperitoneal in rat: 800mg/kg

MSDS

• Language:English Provider:SigmaAldrich

N-Hydroxyurethane Usage And Synthesis

Chemical Properties

Yellow Oil

Uses

Hydroxyurethane is a metabolite of carcinogenic Urethane (U825300).

Uses

Reactant involved in:

• Synthesis of molecules used for intermolecular Sharpless aminohydroxylation reactions
• Intermolecular ortho-C-H amidation of anilides
• Cinchona alkaloid-catalyzed asymmetric cycloaddition
• Allylic arylation

Biochem/physiol Actions

N-Hydroxyurethane causes the chromosomal fragmentation at millimolar concentrations and cell toxicity in cultured normal human leukocytes.

N-Hydroxyurethane(589-41-3)Related Product Information

• Trinexapac-ethyl
• Urethane
• ETHYL ANTHRANILATE
• Benzocaine
• Triethyl orthoformate
• Ethyl acetate
• ISOXADIFEN-ETHYL
• Ethyl acrylate
• Ethyl formate
• Ethanol
• Ethyl cyanoacetate
• Ethylparaben
• Ethyl 4-(butylamino)benzoate
• Ethyl propiolate
• tert-Butyl (Mesitylsulfonyl)oxycarbaMate
• tert-Butyl N-hydroxycarbamate
• Ethyl chloroformate
• BENZYL N-HYDROXYCARBAMATE