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2'-Deoxycytidine-5'-monophosphoric acid

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2'-Deoxycytidine-5'-monophosphoric acid Basic information

Product Name:
2'-Deoxycytidine-5'-monophosphoric acid
Synonyms:
  • 2''-DEOXYCYTIDINE-5''-MONOPHOSPHATE (WRITE CRYSTALLINE POWDER 98-100%)
  • 5''-CYTIDYLIC ACID, 2''-DEOXY-
  • 2''-DEOXYCYTIDINE 5''-MONOPHOSPHATE FREE ACID (DCMP)
  • 2'-Deoxycytidine 5'-Monophosphate Hydrate
  • dCMP, Deoxycytidylic acid
  • 2'-Deoxycytidine-5'-monpohosphate free acid
  • dCMP.H2
  • (2R)-4-(Phosphonomethyl)piperazine-2-carboxylic acid
CAS:
1032-65-1
MF:
C9H14N3O7P
MW:
307.2
EINECS:
213-849-9
Product Categories:
  • Nucleic acids
  • Bases & Related Reagents
  • Pyridines, Pyrimidines, Purines and Pteredines
  • Biochemistry
  • Nucleosides, Nucleotides & Related Reagents
  • Nucleotides and their analogs
  • Carbohydrates & Derivatives
  • Heterocycles
  • Nucleotides
  • Phosphorylating and Phosphitylating Agents
  • Nucleotide
Mol File:
1032-65-1.mol
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2'-Deoxycytidine-5'-monophosphoric acid Chemical Properties

Melting point:
169-172 °C (dec.)
Boiling point:
633.8±65.0 °C(Predicted)
Density 
2.01±0.1 g/cm3(Predicted)
refractive index 
37 ° (C=1, H2O)
storage temp. 
-20°C
solubility 
H2O: 10 mg/mL, clear, colorless
form 
Crystalline Powder
pka
1.86±0.10(Predicted)
color 
White
Water Solubility 
Soluble in water.
BRN 
41062
CAS DataBase Reference
1032-65-1(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
22-24/25-37/39-36-26
WGK Germany 
3
10-21
HS Code 
29349990

MSDS

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2'-Deoxycytidine-5'-monophosphoric acid Usage And Synthesis

Chemical Properties

Crystalline

Uses

A phosphorylated metabolite of the deoxyribonucleoside 2’Deoxycytidine. A constituent of Deoxyribonucleic acid. Studies show that it increases influenza virus antigen-induced immune cell proliferatio n.

Uses

2'-Deoxycytidine-5'-monophosphate is used as a substrate of uridine monophosphate (UMP)/cytidine monophosphate (CMP) kinase (EC 2.7.4.4) to form dCDP which upon phosphorylation to dCTP supports DNA and RNA biosynthesis.

Definition

ChEBI: Dianion of 2'-deoxycytidine 5'-monophosphate arising from deprotonation of both OH groups of the phosphate.

General Description

2′-Deoxycytidine 5′-monophosphate is a deoxynucleotide building block via which DNA is made. It consists of a 2′-deoxy-β-D-ribofuranose, linked through an N-β-D-glycosidic linkage to a heterocycle nitrogen cytosine. It is phosphorylated at carbon C-5′.

Purification Methods

Recrystallise the acid from H2O or aqueous EtOH and dry it in a vacuum. [Volkin et al. J Am Chem Soc 73 1533 1951, UV: Fox et al. J Am Chem Soc 75 4315 1953, IR: Michelson & Todd J Chem Soc 3438 1954, Beilstein 25 IV 3664.]

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