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1,9-DIDEOXYFORSKOLIN

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1,9-DIDEOXYFORSKOLIN Basic information

Product Name:
1,9-DIDEOXYFORSKOLIN
Synonyms:
  • 7BETA-ACETOXY-8,13-EPOXY-6BETA-HYDROXY-LABD-14-EN-11-ONE
  • 7BETA-ACETOXY-6BETA-HYDROXY-8,13-EPOXY-LABD-14-EN-11-ONE
  • Forskolin, 1,9-Dideoxy-, Coleus forskohlii - CAS 64657-18-7 - Calbiochem
  • 1,9-DIDEOXYFORSKOLIN
  • FORSKOLIN, 1,9-DIDEOXY
  • FORSKOLIN, 1,9-DIDEOXY-, COLEUS FORSKOHLII
  • 1,9-DIDEOXYFORSKOLIN FROM COLEUSFORSKOHL II
  • FORSKOLIN, 1,9-DIDEOXY ISOLATED FROM COL EUS
CAS:
64657-18-7
MF:
C22H34O5
MW:
378.5
Mol File:
64657-18-7.mol
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1,9-DIDEOXYFORSKOLIN Chemical Properties

Melting point:
149-150℃
storage temp. 
−20°C
solubility 
methanol: 28 mg/mL
form 
solid
color 
white
optical activity
[α]26/D +93.6°, c = 6.12 in chloroform(lit.)
InChIKey
ZKZMDXUDDJYAIB-OJPJTMFRSA-N
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Safety Information

WGK Germany 
3

MSDS

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1,9-DIDEOXYFORSKOLIN Usage And Synthesis

Description

Forskolin (Item No. 11018) is a naturally-occurring diterpene that activates adenylyl cyclase through its catalytic subunit and is commonly used to raise levels of cAMP in a wide variety of intact cells and tissue preparations. 1,9-dideoxy Forskolin is an analog of forskolin that interacts with, but does not activate, adenylyl cyclase.

Uses

1,9-Dideoxyforkskolin does not activate adenylyl cyclase and is an inactive analog of Forskolin (F701800), a diterpene isolated from Coleus forskohlii, possessing vasodilating and cardiostimulatory properties. Forskolin resensitizes cell receptors by activating the enzyme adenylyl cyclase and increasing the intracellular levels of cAMP.

Definition

ChEBI: A labdane diterpenoid that is the 1,9-dideoxy derivative of forskolin.

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