ChemicalBook > Product Catalog > Pharmaceutical intermediates > Heterocyclic compound > Pyran compounds > 3-CYANO-7-ETHOXYCOUMARIN
3-CYANO-7-ETHOXYCOUMARIN
3-CYANO-7-ETHOXYCOUMARIN Basic information
- Product Name:
- 3-CYANO-7-ETHOXYCOUMARIN
- Synonyms:
-
- 7-Ethoxy-2-oxo-2H-chroMene-3-carbonitrile
- 7-ETHOXYCOUMARIN-3-CARBONITRILE
- 3-CYANO-7-ETHOXYCOUMARIN
- 2H-1-Benzopyran-3-carbonitrile,7-ethoxy-2-oxo-(9CI)
- 7-Ethoxy-2-oxo-2H-1-benzopyran-3-carbonitrile
- 3-Cyano-7-ethoxycoumarin [7-Ethoxycoumarin-3-carbonitrile] *Cytochrome P450 Substrate*
- CEC [3-Cyano-7-ethoxycoumarin] *CAS 117620-77-6*
- CEC [3-Cyano-7-ethoxycoumarin
- CAS:
- 117620-77-6
- MF:
- C12H9NO3
- MW:
- 215.2
- EINECS:
- 200-562-0
- Product Categories:
-
- ETHOXY
- Coumarins
- Multi-Drug Resistance and Drug Metabolism
- Drug and Xenobiotic Metabolism
- Detection and Quantitation
- Reagents
- Substrates, Inducers, Inhibitors
- Mol File:
- 117620-77-6.mol
More
Less
3-CYANO-7-ETHOXYCOUMARIN Chemical Properties
- Melting point:
- 210-212°C
- Boiling point:
- 396.8±42.0 °C(Predicted)
- Density
- 1.29±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: soluble
- form
- Solid
- color
- yellow to orange
- λmax
- 356 nm (Buffer pH7); 355 nm(MeOH)
- Biological Applications
- As a substrate for measuring cytochrome P450 enzymes activity; cytochrome P450 inhibition assays; drug design; drug metabolism; treating viral or parasite infections.
More
Less
Safety Information
- Hazard Codes
- Xn
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-36
- WGK Germany
- 3
MSDS
- Language:English Provider:SigmaAldrich
More
Less
3-CYANO-7-ETHOXYCOUMARIN Usage And Synthesis
Uses
Substrate for determination of cytochrom P-450 dependent oxidases; about 50-100 times more sensitive than conventional substrate ethoxy-resorufin due to higher turn over rate.
Uses
3-Cyano-7-ethoxycoumarin has been used as a substrate in cytochrome P (CYP) inhibition for fluorescence measurement.
General Description
3-Cyano-7-ethoxycoumarin is a fluorescent substrate for Cytochrome P450 1A1 (CYP1A1), Cytochrome P450 1A2 (CYP1A2), Cytochrome P450 2C9 (CYP2C9) and Cytochrome P450 2C19 (CYP2C19).
Biochem/physiol Actions
Fluorescent probe useful in microsomal dealkylase studies. Typical drug-drug interactions resulting from enzyme inhibition.
3-CYANO-7-ETHOXYCOUMARIN Preparation Products And Raw materials
Raw materials
3-CYANO-7-ETHOXYCOUMARINSupplier
Absin Bioscience Inc. Gold
- Tel
- 021-38015121 15000105423
- chenjw@absin.cn
Shanghai Boyle Chemical Co., Ltd.
- Tel
- sales@boylechem.com
Beijing Ouhe Technology Co., Ltd
- Tel
- 010-82967028 13552068683
- 2355560935@qq.com
Haoyuan Chemexpress Co., Ltd.
- Tel
- 021-58950125
- info@chemexpress.com
Shanghai Aladdin Bio-Chem Technology Co.,LTD
- Tel
- 400-6206333 18521732826;
- market@aladdin-e.com