3-CYANO-7-ETHOXYCOUMARIN Chemical Properties

Melting point:

210-212°C

Boiling point:

396.8±42.0 °C(Predicted)

Density 

1.29±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: soluble

form 

Solid

color 

yellow to orange

λmax

356 nm (Buffer pH7); 355 nm(MeOH)

Biological Applications

As a substrate for measuring cytochrome P450 enzymes activity; cytochrome P450 inhibition assays; drug design; drug metabolism; treating viral or parasite infections.

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22-36/37/38

Safety Statements 

26-36

WGK Germany 

3

MSDS

• Language:English Provider:SigmaAldrich

3-CYANO-7-ETHOXYCOUMARIN Usage And Synthesis

Uses

Substrate for determination of cytochrom P-450 dependent oxidases; about 50-100 times more sensitive than conventional substrate ethoxy-resorufin due to higher turn over rate.

Uses

3-Cyano-7-ethoxycoumarin has been used as a substrate in cytochrome P (CYP) inhibition for fluorescence measurement.

General Description

3-Cyano-7-ethoxycoumarin is a fluorescent substrate for Cytochrome P450 1A1 (CYP1A1), Cytochrome P450 1A2 (CYP1A2), Cytochrome P450 2C9 (CYP2C9) and Cytochrome P450 2C19 (CYP2C19).

Biochem/physiol Actions

Fluorescent probe useful in microsomal dealkylase studies. Typical drug-drug interactions resulting from enzyme inhibition.

3-CYANO-7-ETHOXYCOUMARIN(117620-77-6)Related Product Information

• CoumarinDerivatives
• Coumarin-3-carboxylic acid
• Sodium cyanoborohydride
• 7-Ethoxycoumarin
• 3-(3-methoxyphenoxy)propanenitrile
• 7-METHOXY-2H-CHROMENE-3-CARBONITRILE
• 3-Cyano-7-hydroxycoumarin
• 4-METHOXYCINNAMONITRILE
• 3-CYANOCOUMARIN
• 2H-CHROMENE-3-CARBONITRILE
• 3-CYANO-7-ETHOXYCOUMARIN