Basic information Safety Supplier Related

D-(+)-NEOPTERIN

Basic information Safety Supplier Related

D-(+)-NEOPTERIN Basic information

Product Name:
D-(+)-NEOPTERIN
Synonyms:
  • (+)-NEOPTERIN
  • 2-Amino-6-((1S
  • 3-trihydroxypropyl)pteridin-4(3H)-one
  • 2-Amino-6-[(1S,2R)-1,2,3-trihydroxypropyl]-4(3H)-pteridinone
  • NEOPTERIN
  • D-(+)-NEOPTERIN
  • D(+)-6-(ERYTHRO-1,2,3-TRIHYDROXYPROPYL)PTERIN
  • D-ERYTHRO-NEOPTERIN
CAS:
2009-64-5
MF:
C9H11N5O4
MW:
253.21
EINECS:
217-924-7
Product Categories:
  • Bases & Related Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals
Mol File:
2009-64-5.mol
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D-(+)-NEOPTERIN Chemical Properties

Melting point:
>232°C (dec.)
alpha 
D25 +45 ± 3° (c = 0.3 in 0.1N HCl)
Boiling point:
396.41°C (rough estimate)
Density 
1.3957 (rough estimate)
refractive index 
1.7610 (estimate)
storage temp. 
2-8°C
solubility 
Aqueous Acid (Slightly, Sonicated), Aqueous Base (Slightly)
form 
Off-white to yellow solid.
pka
12.60±0.20(Predicted)
color 
Light Orange to Light Brown
Merck 
13,6490
BRN 
89070
Stability:
Hygroscopic
InChIKey
BMQYVXCPAOLZOK-XINAWCOVSA-N
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Safety Information

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26
WGK Germany 
3
23
HS Code 
29335990

MSDS

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D-(+)-NEOPTERIN Usage And Synthesis

Description

Neopterin is a pyrazino-pyrimidine compound derived from GTP that represents an intermediate product in the synthetic pathway of biopterin and is an essential cofactor in neurotransmitter synthesis. Neopterin is released from macrophages upon immune stimulation with interferon-γ from activated T cells. It is routinely used as a biochemical tool to screen for and monitor the progression of certain diseases accompanied by hyperimmune stimulation.

Chemical Properties

off-white to yellow solid

Uses

Precursor in the biosynthesis of Biopterin. First isolated from the pupae of bees.

Uses

D-(+)-Neopterin has been used as a NADPH oxidase inhibitor while assessing the ability of NADPH oxidases in breast cancer cells to produce reactive oxygen species (ROS). [NADPH= nicotinamide adenine dinucleotide phosphate]

General Description

D-(+)-Neopterin is a pteridine derivative, naturally found in Dictyostelium discoideum. It is found in significant amounts in the urine of cancer patients.

Biochem/physiol Actions

Pterin cofactor; precursor of BH4 (tetrahydrobiopterin).

storage

Store at -20°C

Purification Methods

Purification is as for biopterin. Also purify it on a Dowex-1 x 8 (formate form) column and elute with 0.03M ammonium formate buffer pH 8.0 then pH 7.2. The fluorescent neopterin fraction is evaporated under reduced pressure, leaving neopterin and ammonium formate (the latter sublimes out at high vacuum) behind. Stir the residue for 24hours with EtOH, collect the solid and recrystallise it from H2O. [Viscontini et al. Helv Chim Acta 53 1202 1970, cf Wachter et al. Eds Neopterin W de Gruyter, Berlin 1992, ISBN 9783110117905, Beilstein 26 IV 4038.]

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