I-SAP Chemical Properties

Boiling point:

606.3±61.0 °C(Predicted)

Density 

1.51±0.1 g/cm3(Predicted)

storage temp. 

Store at -20°C

solubility 

DMF: >50 mg/ml (from Pinane TXA2); DMSO: >25 mg/ml (from Pinane TXA2); Ethanol: >100 mg/ml (from Pinane TXA2); PBS pH 7.2: >100 μg/ml (from Pinane TXA2)

pka

4.76±0.10(Predicted)

I-SAP Usage And Synthesis

Uses

I-SAP is a radioiodinated TXA2/PGH2 receptor antagonist. The bind between I-SAP and the receptors, is inhibited by the histidine modifying reagent diethyl-pyrocarbonate (DEPC)[1][2].

IC 50

TXA₂ Receptor

References

[1] Saussy DL Jr, et al. Binding of a novel radioiodinated thromboxane A2/prostaglandin H2 antagonist to guinea pig lung membranes. Eicosanoids. 1992;5(1):1-4. PMID:1419073
[2] Schr?r K, et al. Inhibition of ligand binding to thromboxane A2/prostaglandin H2 receptors by diethylpyrocarbonate. Protection by receptor ligands and reversal by hydroxylamine. Biochem Pharmacol. 1995 Mar 30;49(7):921-7. DOI:10.1016/0006-2952(95)00015-r

I-SAP(133538-58-6)Related Product Information

• PINANE
• (1S)-(-)-CIS-PINAME
• 125I-SAP
• 4-iodobenzenesulfonamide
• N-N-OCTYL BENZENESULFONAMIDE
• (+)-ISOPINOCAMPHEYLAMINE
• 4,4-DIMETHYLCYCLOHEXYLAMINE
• 2,3-DIMETHYLCYCLOHEXYLAMINE
• I-SAP